PMID- 18323272
OWN - NLM
STAT- MEDLINE
DCOM- 20080429
LR  - 20180217
IS  - 0001-5547 (Print)
IS  - 0001-5547 (Linking)
VI  - 52
IP  - 1
DP  - 2008 Jan-Feb
TI  - Value of endoscopic retrograde cholangiopancreatography-guided brushings in 
      preoperative assessment of pancreaticobiliary strictures: what's new?
PG  - 24-34
AB  - Brush cytology plays a prominent role in confirming the presence of extrahepatic 
      biliary tract malignancy. However, its value is limited by its relatively low and 
      widely variable sensitivity values. Various factors seem to influence the 
      accuracy of cytologic diagnosis and are attributed to sampling, technical and 
      interpretation errors. Ancillary methods, such as immunocytochemistry, flow 
      cytometry, image analysis, fluorescence in situ hybridization (FISH) and the 
      newly discovered method of global analysis of gene expression are helpful in 
      resolving cases with inconclusive cytology and are vigorously investigated for 
      their value in assessing the expression of novel tumor markers for the diagnosis 
      and prognosis of pancreatic and bile duct carcinomas. However, their routine use 
      in clinical practice remains in doubt. To increase the sensitivity of brush 
      cytology and strengthen its role in the preoperative assessment of patients with 
      pancreaticobiliary malignancies, the following are of the utmost importance: 
      improvement of current sampling and cytopreparation techniques, introduction of a 
      uniform system for reporting epithelial abnormalities based on strict and clearly 
      distinct morphologic criteria for each pathologic entity and incorporation of 
      experience and knowledge derived from standard cytologic methods and novel 
      diagnostic technologies in clinical practice without compromising the high 
      specificity associated with brush cytology.
FAU - Athanassiadou, Pauline
AU  - Athanassiadou P
AD  - Pathology Laboratory, Department of Cytology, Medical School, University of 
      Athens, Athens, Greece.
FAU - Grapsa, Dimitra
AU  - Grapsa D
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Switzerland
TA  - Acta Cytol
JT  - Acta cytologica
JID - 0370307
SB  - IM
MH  - Adenocarcinoma/*diagnosis/pathology
MH  - Bile Ducts/*pathology
MH  - Biliary Tract Neoplasms/*diagnosis/pathology
MH  - Cholangiopancreatography, Endoscopic Retrograde/*methods
MH  - Humans
MH  - Pancreatic Ducts/*pathology
MH  - Pancreatic Neoplasms/*diagnosis/pathology
RF  - 119
EDAT- 2008/03/08 09:00
MHDA- 2008/04/30 09:00
CRDT- 2008/03/08 09:00
PHST- 2008/03/08 09:00 [pubmed]
PHST- 2008/04/30 09:00 [medline]
PHST- 2008/03/08 09:00 [entrez]
AID - 10.1159/000325431 [doi]
PST - ppublish
SO  - Acta Cytol. 2008 Jan-Feb;52(1):24-34. doi: 10.1159/000325431.