PMID- 18324507
OWN - NLM
STAT- MEDLINE
DCOM- 20080619
LR  - 20080307
IS  - 1381-4788 (Print)
IS  - 1381-4788 (Linking)
VI  - 13
IP  - 4
DP  - 2007
TI  - Angiotensin-converting enzyme inhibitor (ACE-I)- and angiotensin receptor blocker 
      (ARB)-related angioedema: a neglected issue in daily practice in Greece.
PG  - 239-41
LID - 10.1080/13814780701627396 [doi]
AB  - Several reports on angioedema (AE) related to the use of angiotensin-converting 
      enzyme inhibitors (ACE-I) and angiotensin receptor blockers (ARB) have been 
      published recently. This study reports on the experience gained at the Ear, Nose, 
      and Throat (ENT) Clinic of the University Hospital of Heraklion, Crete. A 
      retrospective chart review of the patients admitted to this clinic, in a 42-month 
      period (1999-2003), and discharged with a diagnosis ENT code for AE was performed 
      (14 eligible patients). A complementary telephone survey was conducted during 
      January 2005. Ten patients responded to our invitation. Of those patients, five 
      were under ACE-I and one was under ARB treatment during the AE episode. The mean 
      length of time between the onset of symptoms and presentation to the hospital was 
      4.5 hours (range 0.5-12 hours). The mean duration between the initiation of 
      antihypertensive treatment and AE episode was 26.2 months (range 1-60 months). 
      Patients reported that no information was provided about the possible adverse 
      effects of these drugs. Although AE introduced by ACE-I and ARBs is an uncommon 
      side effect, this case series conveys a key message to primary care physicians.
FAU - Symvoulakis, Emmanouil K
AU  - Symvoulakis EK
AD  - Clinic of Social and Family Medicine, Department of Social Medicine, Faculty of 
      Medicine, University of Crete, Heraklion, Crete, Greece.
FAU - Kyrmizakis, Dionysios E
AU  - Kyrmizakis DE
FAU - Drivas, Emmanouil I
AU  - Drivas EI
FAU - Bizakis, John
AU  - Bizakis J
FAU - Velegrakis, George A
AU  - Velegrakis GA
FAU - Lionis, Christos
AU  - Lionis C
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur J Gen Pract
JT  - The European journal of general practice
JID - 9513566
RN  - 0 (Angiotensin II Type 1 Receptor Blockers)
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
SB  - IM
MH  - Age of Onset
MH  - Aged
MH  - Angioedema/*chemically induced/diagnosis/epidemiology
MH  - Angiotensin II Type 1 Receptor Blockers/*adverse effects
MH  - Angiotensin-Converting Enzyme Inhibitors/*adverse effects
MH  - Female
MH  - Greece/epidemiology
MH  - Humans
MH  - Male
MH  - Medical Audit
MH  - Middle Aged
MH  - Primary Health Care
MH  - Retrospective Studies
MH  - Time Factors
EDAT- 2008/03/08 09:00
MHDA- 2008/06/20 09:00
CRDT- 2008/03/08 09:00
PHST- 2008/03/08 09:00 [pubmed]
PHST- 2008/06/20 09:00 [medline]
PHST- 2008/03/08 09:00 [entrez]
AID - 791263880 [pii]
AID - 10.1080/13814780701627396 [doi]
PST - ppublish
SO  - Eur J Gen Pract. 2007;13(4):239-41. doi: 10.1080/13814780701627396.