PMID- 18325183
OWN - NLM
STAT- MEDLINE
DCOM- 20080605
LR  - 20111117
IS  - 0004-5632 (Print)
IS  - 0004-5632 (Linking)
VI  - 45
IP  - Pt 2
DP  - 2008 Mar
TI  - Cardiac troponin I measurement using the ACS:180 to predict four-year cardiac 
      event rate.
PG  - 184-8
LID - 10.1258/acb.2007.007050 [doi]
AB  - BACKGROUND: This study aimed at evaluating the ability of cardiac troponin I 
      (cTnI) measurement on the ACS:180 for prognostic risk stratification. Sequential 
      admissions to the coronary care unit of a busy district general hospital were 
      studied. All patients were followed up for a maximum of 4.3 years and cardiac 
      events, either cardiac death, readmission with acute myocardial infarction or 
      admission with acute unstable angina were documented. METHODS: Blood samples were 
      taken on admission and at 4 and 12 h. A serum aliquot was taken and stored frozen 
      at -70 degrees C. The frozen aliquots were subsequently analysed for cTnI by 
      chemiluminescent immunoassay using an ACS:180. Patients were categorized into 
      those with or without ST segment elevation on the presenting electrocardiogram. 
      The optimized decision threshold for mortality and event prediction was then 
      determined by log-rank analysis and by construction of Kaplan-Meier survival 
      plots. RESULTS: A total of 289 patients (196 men) median age 65.3 years, range 
      27.4-87.9 years were studied. Out of this, 139 had ST elevation myocardial 
      infarction (STEMI) and 150 had suspected non-STEMI (NSTEMI). Full data were 
      available from 278 patients. Admission cTnI did not predict any of the endpoints 
      in the STEMI group. In patients admitted with suspected NSTEMI, admission and 
      peak cTnI predicted increased risk of death or readmission with acute myocardial 
      infarction. In addition, peak cTnI predicted increased risk of death. CONCLUSION: 
      A cTnI exceeding 0.16 microg/L on admission or during hospital stay predicted an 
      increased cardiac event rate at four years in patients admitted with suspected 
      NSTEMI.
FAU - Collinson, Paul O
AU  - Collinson PO
AD  - Department of Chemical Pathology, 2nd Floor Jenner Wing, St George's Hospital and 
      Medical School, Blackshaw Road, London SW17 0QT, UK. 
      paul.collinson@stgeorges.nhs.uk
FAU - Gaynor, Gloria H
AU  - Gaynor GH
FAU - Gaze, David C
AU  - Gaze DC
LA  - eng
PT  - Journal Article
PL  - England
TA  - Ann Clin Biochem
JT  - Annals of clinical biochemistry
JID - 0324055
RN  - 0 (Troponin I)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Angina, Unstable/diagnosis/metabolism/mortality
MH  - Cohort Studies
MH  - Follow-Up Studies
MH  - Humans
MH  - Luminescent Measurements
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*diagnosis/metabolism/mortality
MH  - Risk Factors
MH  - Troponin I/*blood
EDAT- 2008/03/08 09:00
MHDA- 2008/06/06 09:00
CRDT- 2008/03/08 09:00
PHST- 2008/03/08 09:00 [pubmed]
PHST- 2008/06/06 09:00 [medline]
PHST- 2008/03/08 09:00 [entrez]
AID - 10.1258/acb.2007.007050 [doi]
PST - ppublish
SO  - Ann Clin Biochem. 2008 Mar;45(Pt 2):184-8. doi: 10.1258/acb.2007.007050.