PMID- 18325670
OWN - NLM
STAT- MEDLINE
DCOM- 20080728
LR  - 20131121
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 435
IP  - 1
DP  - 2008 Apr 11
TI  - Association between the brain-derived neurotrophic factor Val66Met polymorphism 
      and brain morphology in a Japanese sample of schizophrenia and healthy 
      comparisons.
PG  - 34-9
LID - 10.1016/j.neulet.2008.02.004 [doi]
AB  - Magnetic resonance imaging was used to investigate the relation between the 
      brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and volumetric 
      measurements for the medial temporal lobe structures (amygdala, hippocampus, and 
      parahippocampal gyrus) and prefrontal sub-regions (the superior frontal gyrus, 
      middle frontal gyrus, inferior frontal gyrus, ventral medial prefrontal cortex, 
      orbitofrontal cortex, and straight gyrus) in a Japanese sample of 33 
      schizophrenia patients and 29 healthy subjects. For the controls, the Met 
      carriers had significantly smaller parahippocampal and left superior frontal gyri 
      than the Val homozygotes. The schizophrenia patients carrying the Met allele had 
      a significantly smaller right parahippocampal gyrus than those with the Val/Val 
      genotype, but the genotype did not affect the prefrontal regions in schizophrenia 
      patients. These findings might reflect different genotypic effects of BDNF on 
      brain morphology in schizophrenia patients and healthy controls, implicating the 
      possible role of the brain morphology as an endophenotype for future genetic 
      studies in schizophrenia.
FAU - Takahashi, Tsutomu
AU  - Takahashi T
AD  - Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 
      930-0194, Japan.
FAU - Suzuki, Michio
AU  - Suzuki M
FAU - Tsunoda, Masahiko
AU  - Tsunoda M
FAU - Kawamura, Yukiko
AU  - Kawamura Y
FAU - Takahashi, Nagahide
AU  - Takahashi N
FAU - Tsuneki, Hiroshi
AU  - Tsuneki H
FAU - Kawasaki, Yasuhiro
AU  - Kawasaki Y
FAU - Zhou, Shi-Yu
AU  - Zhou SY
FAU - Kobayashi, Soushi
AU  - Kobayashi S
FAU - Sasaoka, Toshiyasu
AU  - Sasaoka T
FAU - Seto, Hikaru
AU  - Seto H
FAU - Kurachi, Masayoshi
AU  - Kurachi M
FAU - Ozaki, Norio
AU  - Ozaki N
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080209
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Genetic Markers)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adult
MH  - Amino Acid Substitution/genetics
MH  - Atrophy/metabolism/pathology/physiopathology
MH  - Brain/metabolism/*pathology/physiopathology
MH  - Brain-Derived Neurotrophic Factor/chemistry/*genetics
MH  - DNA Mutational Analysis
MH  - Female
MH  - Functional Laterality/genetics
MH  - Gene Frequency/genetics
MH  - Genetic Markers/genetics
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genetic Testing
MH  - Genotype
MH  - Humans
MH  - Japan
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Methionine/genetics
MH  - Parahippocampal Gyrus/metabolism/pathology/physiopathology
MH  - Polymorphism, Genetic/*genetics
MH  - Schizophrenia/*genetics/metabolism/*pathology
MH  - Valine/genetics
EDAT- 2008/03/08 09:00
MHDA- 2008/07/29 09:00
CRDT- 2008/03/08 09:00
PHST- 2007/11/18 00:00 [received]
PHST- 2008/01/31 00:00 [revised]
PHST- 2008/02/04 00:00 [accepted]
PHST- 2008/03/08 09:00 [pubmed]
PHST- 2008/07/29 09:00 [medline]
PHST- 2008/03/08 09:00 [entrez]
AID - S0304-3940(08)00175-4 [pii]
AID - 10.1016/j.neulet.2008.02.004 [doi]
PST - ppublish
SO  - Neurosci Lett. 2008 Apr 11;435(1):34-9. doi: 10.1016/j.neulet.2008.02.004. Epub 
      2008 Feb 9.