PMID- 18326229
OWN - NLM
STAT- MEDLINE
DCOM- 20080401
LR  - 20151119
IS  - 0040-3660 (Print)
IS  - 0040-3660 (Linking)
VI  - 80
IP  - 1
DP  - 2008
TI  - [Urinary excretion of proinflammatory cytokines and transforming growth factor 
      beta at early stages of diabetic nephropathy].
PG  - 52-6
AB  - AIM: To examine correlations between urine excretion of proinflammatory 
      cytokines, transforming growth factor beta (TGF-b) and changes in renal structure 
      and function, quality of glycemia control in patients with type 1 diabetes 
      mellitus. MATERIAL AND METHODS: Urinary excretion of interleukine 1-beta (IL-1b), 
      monocytic chemoattractive protein-1 (MCP-1), RANTES and TGF-b was measured with 
      enzyme immunoassay in 57 patients including 22 patients with normal albuminuria, 
      23--with microalbuminuria, 12--with macroalbuminuria. Creatinine clearance was 
      subnormal in 8 patients with macroalbuminuria. The control group consisted of 10 
      healthy persons. Morphological examination of renal biopsies was performed in 8 
      patients with normoalbuminuria and 10 patients with microalbuminuria. RESULTS: 
      Patients with normoalbuminuria had excretion of MCP-1 significantly higher than 
      in controls. Microalbuminuria patients showed high excretion of IL-1b, MCP-1 and 
      TGF-b. Excretion of IL-1b, MCP-1, RANTES and TGF-b in patients with 
      macroalbuminuria was higher than in controls and other groups of patients. 
      Excretion of cytokines and TGFb correlated inversely with glomerular filtration 
      rate and hemoglobin level. Positive correlations were detected between excretion 
      of IL-1b, MCP-1, TGFb and glycated hemoglobin A(1c). In patients with normo- and 
      microalbuminuria cytokine and TGFb excretion correlated with thickness of 
      glomerular and glomerular basal membrane. CD68-positive macrophages were detected 
      in the intersticium of 1 patient with normoalbuminuria and 6 patients with 
      microalbuminuria. CONCLUSION: Urinary excretion of proinflammatory cytokines and 
      TGF-b was elevated in patients with DM-1 having micro- and macroalbuminuria 
      suggesting participation of inflammation in development of diabetic nephropathy.
FAU - Bondar', I A
AU  - Bondar' IA
FAU - Klimontov, V V
AU  - Klimontov VV
FAU - Nadeev, A P
AU  - Nadeev AP
LA  - rus
PT  - English Abstract
PT  - Journal Article
PL  - Russia (Federation)
TA  - Ter Arkh
JT  - Terapevticheskii arkhiv
JID - 2984818R
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation, Myelomonocytic)
RN  - 0 (Biomarkers)
RN  - 0 (CD68 antigen, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL5)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Transforming Growth Factor beta)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Albuminuria/etiology/pathology/urine
MH  - Antigens, CD/immunology
MH  - Antigens, Differentiation, Myelomonocytic/immunology
MH  - Biomarkers/urine
MH  - Chemokine CCL2/*urine
MH  - Chemokine CCL5/*urine
MH  - Diabetic Retinopathy/complications/physiopathology/*urine
MH  - Female
MH  - Follow-Up Studies
MH  - Glomerular Basement Membrane/pathology
MH  - Glomerular Filtration Rate/physiology
MH  - Humans
MH  - Inflammation/pathology/urine
MH  - Interleukin-1beta/*urine
MH  - Macrophages/immunology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Severity of Illness Index
MH  - Transforming Growth Factor beta/*urine
EDAT- 2008/03/11 09:00
MHDA- 2008/04/02 09:00
CRDT- 2008/03/11 09:00
PHST- 2008/03/11 09:00 [pubmed]
PHST- 2008/04/02 09:00 [medline]
PHST- 2008/03/11 09:00 [entrez]
PST - ppublish
SO  - Ter Arkh. 2008;80(1):52-6.