PMID- 18326550
OWN - NLM
STAT- MEDLINE
DCOM- 20080729
LR  - 20151119
IS  - 1464-3502 (Electronic)
IS  - 0735-0414 (Linking)
VI  - 43
IP  - 3
DP  - 2008 May-Jun
TI  - Alterations of serum brain-derived neurotrophic factor levels in early alcohol 
      withdrawal.
PG  - 241-5
LID - 10.1093/alcalc/agm172 [doi]
AB  - AIMS: Alcohol withdrawal-enhanced neurotoxicity contributes to the addictive 
      process. Brain-derived neurotrophic factor (BDNF) plays an important role in 
      neuronal plasticity and learning. In this study, we explored the changes of serum 
      BDNF levels in alcoholic patients at baseline and after one-week alcohol 
      withdrawal. METHODS: Twenty-five alcoholic patients were admitted for alcohol 
      detoxification treatment, and 22 healthy control subjects were also enrolled. We 
      collected blood samples of the patient group on the first and seventh day of 
      alcohol withdrawal, and measured serum BDNF level with sandwich enzyme-linked 
      immunosorbent assay. The severity of withdrawal symptoms was evaluated by the 
      Clinical Institute Withdrawal Assessment-Alcohol, Revised every eight hours. 
      RESULTS: Serum BDNF levels did not differ significantly between alcoholic 
      patients and control subjects. But BDNF levels were found to be significantly 
      increased one week after alcohol withdrawal (from 13.9 +/- 3.8 ng/ml to 15.4 +/- 
      3.8 ng/ml, P = 0.03). A significant positive correlation was found between 
      baseline BDNF level and baseline withdrawal severity (r = 0.45, P = 0.03). 
      CONCLUSIONS: The present study suggests that elevated serum BDNF levels were 
      found in early alcohol withdrawal, implying that BDNF may involve in 
      neuroadaptation during the period.
FAU - Huang, Ming-Chyi
AU  - Huang MC
AD  - Department of Psychiatry, Taipei City Psychiatric Center, Taipei City Hospital, 
      Taipei, Taiwan.
FAU - Chen, Chun-Hsin
AU  - Chen CH
FAU - Chen, Chia-Hui
AU  - Chen CH
FAU - Liu, Shing-Cheng
AU  - Liu SC
FAU - Ho, Chia-Jen
AU  - Ho CJ
FAU - Shen, Winston W
AU  - Shen WW
FAU - Leu, Sy-Jye
AU  - Leu SJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080307
PL  - England
TA  - Alcohol Alcohol
JT  - Alcohol and alcoholism (Oxford, Oxfordshire)
JID - 8310684
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Alcoholism/*blood/diagnosis/psychology
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/biosynthesis/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Substance Withdrawal Syndrome/*blood/diagnosis/psychology
MH  - Time Factors
EDAT- 2008/03/11 09:00
MHDA- 2008/07/30 09:00
CRDT- 2008/03/11 09:00
PHST- 2008/03/11 09:00 [pubmed]
PHST- 2008/07/30 09:00 [medline]
PHST- 2008/03/11 09:00 [entrez]
AID - agm172 [pii]
AID - 10.1093/alcalc/agm172 [doi]
PST - ppublish
SO  - Alcohol Alcohol. 2008 May-Jun;43(3):241-5. doi: 10.1093/alcalc/agm172. Epub 2008 
      Mar 7.