PMID- 18327088
OWN - NLM
STAT- MEDLINE
DCOM- 20080708
LR  - 20171116
IS  - 0263-6352 (Print)
IS  - 0263-6352 (Linking)
VI  - 26
IP  - 4
DP  - 2008 Apr
TI  - Evidence for no global effect of metabolic syndrome per se on early hypertensive 
      sequelae.
PG  - 773-9
LID - 10.1097/HJH.0b013e3282f430b0 [doi]
AB  - OBJECTIVE: In the present study we assessed the impact of metabolic syndrome (MS) 
      and its components on markers of cardiovascular and renal damage in a population 
      of essential hypertensives. METHODS: A total of 651 consecutive, untreated and 
      non-diabetic hypertensives (age 54 +/- 12 years, 340 males) who were included in 
      the 3H Study, an ongoing registry of hypertension-related target organ damage, 
      were considered for analysis. Left ventricular mass was indexed both for body 
      surface area (LVMBSA) and for height2.7 (LVMheight2.7). Diastolic function was 
      estimated by means of both conventional and tissue Doppler imaging (TDI) methods. 
      Arterial stiffness was evaluated on the basis of carotid to femoral pulse wave 
      velocity (c-f PWV) and microalbuminuria (MA) as albumin to creatinine ratio (ACR) 
      22-300 mg/g in men and 31-300 mg/g in women in two non-consecutive morning spot 
      urine samples. RESULTS: MS (Adult Treatment Panel III criteria) was present in 
      201 hypertensives (30.9%). Hypertensives with MS had increased logACR (by 10%, P 
      = 0.01) and higher prevalence of MA (17 versus 8%, P < 0.001). Both groups 
      exhibited similar values of LVMBSA, transmitral and TDI-derived indexes and c-f 
      PWV (NS for all) while LVMheight2.7 was significantly higher in hypertensives 
      with MS (by 2.6 g/m2.7, P = 0.023). Multiple regression analysis revealed that MS 
      was an independent predictor only of logACR (beta = 0.110, P = 0.007) and MA 
      (odds ratio = 2.577, P < 0.001), while components of blood pressure affected all 
      studied indices of organ damage. CONCLUSIONS: MS per se does not deteriorate 
      cardiac adaptations and aortic stiffness beyond haemodynamic load in 
      hypertension. The MS-related unfavourable effect is limited to the level of the 
      glomerulus.
FAU - Tsioufis, Costas
AU  - Tsioufis C
AD  - Department of Cardiology, Hippokration Hospital, Athens, Greece. 
      ktsioufis@hippocratio.gr
FAU - Tsiachris, Dimitris
AU  - Tsiachris D
FAU - Dimitriadis, Kyriakos
AU  - Dimitriadis K
FAU - Chartzoulakis, George
AU  - Chartzoulakis G
FAU - Selima, Maria
AU  - Selima M
FAU - Chatzis, Dimitris
AU  - Chatzis D
FAU - Taxiarchou, Efstathios
AU  - Taxiarchou E
FAU - Stefanadis, Christodoulos
AU  - Stefanadis C
FAU - Kallikazaros, Ioannis
AU  - Kallikazaros I
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Hypertens
JT  - Journal of hypertension
JID - 8306882
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Albuminuria/diagnosis/*epidemiology
MH  - Biomarkers
MH  - Blood Flow Velocity
MH  - Cohort Studies
MH  - Echocardiography
MH  - Female
MH  - Humans
MH  - Hypertension, Renal/diagnosis/*epidemiology/physiopathology
MH  - Logistic Models
MH  - Male
MH  - Metabolic Syndrome/*epidemiology
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Pulsatile Flow
MH  - Registries
MH  - Risk Factors
MH  - Ventricular Dysfunction, Left/diagnostic imaging/*epidemiology
EDAT- 2008/03/11 09:00
MHDA- 2008/07/09 09:00
CRDT- 2008/03/11 09:00
PHST- 2008/03/11 09:00 [pubmed]
PHST- 2008/07/09 09:00 [medline]
PHST- 2008/03/11 09:00 [entrez]
AID - 00004872-200804000-00024 [pii]
AID - 10.1097/HJH.0b013e3282f430b0 [doi]
PST - ppublish
SO  - J Hypertens. 2008 Apr;26(4):773-9. doi: 10.1097/HJH.0b013e3282f430b0.