PMID- 18327662
OWN - NLM
STAT- MEDLINE
DCOM- 20080729
LR  - 20081121
IS  - 1420-682X (Print)
IS  - 1420-682X (Linking)
VI  - 65
IP  - 11
DP  - 2008 Jun
TI  - Central role of dendritic cells in the regulation and deregulation of immune 
      responses.
PG  - 1683-97
LID - 10.1007/s00018-008-8009-2 [doi]
AB  - Dendritic cells (DCs) play a critical role in orchestrating the innate and 
      adaptive components of the immune system so that appropriate, coordinated 
      responses are mounted against infectious agents. Tissue-resident DCs interact 
      with microbes through germline-encoded pattern-recognition receptors (PRRs), 
      which recognize molecular patterns expressed by various microorganisms. Antigens 
      use PRR activation to instruct DCs for the appropriate priming of natural killer 
      (NK) cells, followed by specific T-cell responses. Due to the central role of DCs 
      in regulating the activation and progression of immune responses, minor 
      imbalances in the feedback control of Toll-like receptor (TLR)-activated cells 
      have been associated with autoimmunity in genetically prone individuals. We 
      review here recent findings on the role of DCs in the priming of innate and 
      adaptive immune responses and the possible involvement of DCs in inducing and 
      maintaining autoimmune reactions.
FAU - Granucci, F
AU  - Granucci F
AD  - Department of Biotechnology and Bioscience, University of Milano-Bicocca, Piazza 
      della Scienza 2, Milan, Italy. francesca.granucci@unimib.it
FAU - Zanoni, I
AU  - Zanoni I
FAU - Ricciardi-Castagnoli, P
AU  - Ricciardi-Castagnoli P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Switzerland
TA  - Cell Mol Life Sci
JT  - Cellular and molecular life sciences : CMLS
JID - 9705402
RN  - 0 (Antigens)
RN  - 0 (Receptors, Pattern Recognition)
RN  - 0 (Toll-Like Receptors)
SB  - IM
MH  - Antigens/immunology
MH  - Autoimmunity/immunology
MH  - Dendritic Cells/cytology/*immunology
MH  - Humans
MH  - Immune System/*physiology
MH  - Immunity, Innate/immunology
MH  - Killer Cells, Natural/immunology
MH  - Lymphocyte Activation
MH  - Receptors, Pattern Recognition/*immunology
MH  - T-Lymphocytes/immunology
MH  - Toll-Like Receptors/immunology
RF  - 172
EDAT- 2008/03/11 09:00
MHDA- 2008/07/30 09:00
CRDT- 2008/03/11 09:00
PHST- 2008/03/11 09:00 [pubmed]
PHST- 2008/07/30 09:00 [medline]
PHST- 2008/03/11 09:00 [entrez]
AID - 10.1007/s00018-008-8009-2 [doi]
PST - ppublish
SO  - Cell Mol Life Sci. 2008 Jun;65(11):1683-97. doi: 10.1007/s00018-008-8009-2.