PMID- 18328265
OWN - NLM
STAT- MEDLINE
DCOM- 20081020
LR  - 20080415
IS  - 1873-2933 (Electronic)
IS  - 0009-9120 (Linking)
VI  - 41
IP  - 7-8
DP  - 2008 May
TI  - Association of high sensitivity C-reactive protein (hsCRP) and tumour necrosis 
      factor-alpha (TNF-alpha) with carotid intimal medial thickness in subjects with 
      different grades of glucose intolerance--the Chennai Urban Rural Epidemiology 
      Study (CURES-31).
PG  - 480-5
LID - 10.1016/j.clinbiochem.2008.01.030 [doi]
AB  - OBJECTIVE: To assess the association of high sensitivity C-Reactive Protein 
      [hsCRP] and Tumour Necrosis Factor-alpha [TNF-alpha] with IMT in Asian Indians 
      with different grades of glucose intolerance. DESIGN AND METHODS: Subjects with 
      normal glucose tolerance [NGT](n=150), impaired glucose tolerance [IGT] (n=150) 
      and type 2 diabetes (DM) (n=150) were recruited from the Chennai Urban Rural 
      Epidemiology Study [CURES], in south India. hsCRP was estimated by nephelometry 
      and TNF-alpha by enzyme linked immunosorbent assay. Carotid IMT was assessed by 
      high resolution B-mode ultrasonography. RESULTS: hsCRP and TNF-alpha levels were 
      higher in those with DM [p<0.001] and IGT [p<0.001] compared to NGT. In linear 
      regression analysis, both hsCRP [p=0.003] and TNF-alpha [p=0.001] showed an 
      association with IMT among NGT subjects even after adjusting for age and gender. 
      Among IGT subjects, TNF-alpha was associated with IMT [p<0.001], while no 
      association was observed either with hsCRP or TNF-alpha in diabetic subjects. In 
      NGT subjects, mean IMT was highest in those with high values [III tertile] of 
      both TNF-alpha and hsCRP [0.83+/-0.1 mm; p<0.001] followed by those with high 
      TNF-alpha+low hsCRP [0.74+/-0.09 mm; p<0.001], high hsCRPlow TNF-alpha 
      [0.67+/-0.09 mm; p<0.001], and lowest in those with both low TNF-alpha and hsCRP 
      [I tertile] [0.63+/-0.05 mm. CONCLUSION: We conclude that in Asian Indians 1. 
      Levels of hsCRP and TNF-alpha increase with increasing severity of glucose 
      intolerance 2. Both hsCRP and TNF-alpha are associated with IMT in NGT subjects 
      while TNF-alpha alone is associated with IMT in IGT subjects 3. hsCRP and 
      TNF-alpha have a cumulative effect on mean IMT values in NGT subjects.
FAU - Gokulakrishnan, Kuppan
AU  - Gokulakrishnan K
AD  - Madras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialities Centre, 
      Gopalapuram, Chennai, India.
FAU - Deepa, Raj
AU  - Deepa R
FAU - Mohan, Viswanathan
AU  - Mohan V
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080221
PL  - United States
TA  - Clin Biochem
JT  - Clinical biochemistry
JID - 0133660
RN  - 0 (Blood Glucose)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Blood Glucose/physiology
MH  - C-Reactive Protein/metabolism/*physiology
MH  - Carotid Artery Diseases/epidemiology/*physiopathology
MH  - Diabetes Mellitus, Type 2/blood/epidemiology/physiopathology
MH  - Female
MH  - Glucose Intolerance/*blood/*epidemiology
MH  - Glucose Tolerance Test
MH  - Humans
MH  - India/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Rural Population
MH  - Tumor Necrosis Factor-alpha/blood/*physiology
MH  - Tunica Intima/pathology/*physiology
MH  - Urban Population
EDAT- 2008/03/11 09:00
MHDA- 2008/10/22 09:00
CRDT- 2008/03/11 09:00
PHST- 2007/08/11 00:00 [received]
PHST- 2008/01/11 00:00 [revised]
PHST- 2008/01/31 00:00 [accepted]
PHST- 2008/03/11 09:00 [pubmed]
PHST- 2008/10/22 09:00 [medline]
PHST- 2008/03/11 09:00 [entrez]
AID - S0009-9120(08)00078-7 [pii]
AID - 10.1016/j.clinbiochem.2008.01.030 [doi]
PST - ppublish
SO  - Clin Biochem. 2008 May;41(7-8):480-5. doi: 10.1016/j.clinbiochem.2008.01.030. 
      Epub 2008 Feb 21.