PMID- 18328444
OWN - NLM
STAT- MEDLINE
DCOM- 20080729
LR  - 20220316
IS  - 1567-5769 (Print)
IS  - 1567-5769 (Linking)
VI  - 8
IP  - 4
DP  - 2008 Apr
TI  - AIP1, a carbohydrate fraction from Artemisia iwayomogi, modulates the functional 
      differentiation of bone marrow-derived dendritic cells.
PG  - 534-41
LID - 10.1016/j.intimp.2007.12.005 [doi]
AB  - Dendritic cells (DCs) are the most potent antigen-presenting cells (APC) 
      particularly important in the initiation of primary T cell-mediated immune 
      responses. Thus, inhibition of the differentiation and function of DC could lead 
      to the suppression of immunological hyperresponsiveness. Artemisia iwayomogi, a 
      member of the Compositae, is a perennial herb easily found in Korea and has been 
      used as a traditional anti-inflammatory medicine. We investigated suppressive 
      effects of carbohydrate fraction 1 from the water extracts of A. iwayomogi (AIP1) 
      on the differentiation and function of bone marrow-derived dendritic cells. Bone 
      marrow cells were cultured in the presence of granulocyte monocyte-colony 
      stimulating factor (GM-CSF) and interleukin (IL)-4 for 6-7 days. Then, 
      non-adherent cells were harvested for subsequent analyses. Percentage(s) of 
      CD11c+ MHC II+ cell population(s) mostly composed of immature or mature DC and 
      the allogeneic T cell stimulating ability of the cells were reduced by AIP1. 
      Proteomic analyses along with RT-PCR revealed that expressions of several 
      proteins including TNF receptor-associated factor (TRAF) 5-like protein, pyruvate 
      kinase M2 (PKM2), and coactosin-like protein 1 (CLP1) were down-regulated upon 
      AIP1 treatment.
FAU - Lee, Jin-Ah
AU  - Lee JA
AD  - Department of Biology, Changwon National University, #9, Sarim-dong, Changwon, 
      Kyungnam 641-773, South Korea.
FAU - Sung, Ha-Na
AU  - Sung HN
FAU - Jeon, Chang-Hwan
AU  - Jeon CH
FAU - Gill, Byoung-Chul
AU  - Gill BC
FAU - Oh, Gap-Soo
AU  - Oh GS
FAU - Youn, Hyun-Joo
AU  - Youn HJ
FAU - Park, Joo-Hung
AU  - Park JH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080116
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (Carbohydrates)
RN  - 0 (Plant Extracts)
RN  - 0 (Proteome)
RN  - 207137-56-2 (Interleukin-4)
RN  - 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
SB  - IM
MH  - Animals
MH  - Artemisia/*chemistry
MH  - Carbohydrates/*pharmacology
MH  - Cell Differentiation/drug effects
MH  - Cell Proliferation/drug effects
MH  - Dendritic Cells/cytology/*drug effects/*immunology/metabolism
MH  - Granulocyte-Macrophage Colony-Stimulating Factor/immunology
MH  - Interleukin-4/immunology
MH  - Lymphocyte Activation/drug effects
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Plant Extracts/isolation & purification/*pharmacology
MH  - Proteome/metabolism
MH  - T-Lymphocytes/immunology
EDAT- 2008/03/11 09:00
MHDA- 2008/07/30 09:00
CRDT- 2008/03/11 09:00
PHST- 2007/09/12 00:00 [received]
PHST- 2007/12/14 00:00 [revised]
PHST- 2007/12/14 00:00 [accepted]
PHST- 2008/03/11 09:00 [pubmed]
PHST- 2008/07/30 09:00 [medline]
PHST- 2008/03/11 09:00 [entrez]
AID - S1567-5769(07)00386-4 [pii]
AID - 10.1016/j.intimp.2007.12.005 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2008 Apr;8(4):534-41. doi: 10.1016/j.intimp.2007.12.005. 
      Epub 2008 Jan 16.