PMID- 18328987
OWN - NLM
STAT- MEDLINE
DCOM- 20080807
LR  - 20211203
IS  - 1521-6942 (Print)
IS  - 1521-6942 (Linking)
VI  - 22
IP  - 1
DP  - 2008 Mar
TI  - Multiple endocrine neoplasms.
PG  - 149-63
LID - 10.1016/j.berh.2007.11.010 [doi]
AB  - Multiple endocrine neoplasia type 1 (MEN1) and type 2 (MEN2) are rare 
      autosomal-dominant disorders characterized by primary tumours in at least two 
      different endocrine tissues. Both syndromes present as sporadic (a single case 
      with two of the characteristic endocrine tumours) or familial form (an MEN case 
      plus at least one first-degree relative showing one of the characteristic 
      endocrine tumours). MEN1 is characterized by the occurrence of parathyroid, 
      gastro-entero-pancreatic and anterior pituitary tumours, but it can include 
      various combinations of more than 20 endocrine and non-endocrine tumours. 
      Generally, tumours in MEN1 are benign, although gastrinomas and foregut 
      carcinoids may exhibit a malignant course. MEN2 is characterized by medullary 
      thyroid carcinoma (MTC), uni- or bi-lateral pheochromocytoma, and other tumours 
      of different endocrine tissues. If not diagnosed precociously, MTC can be fatal. 
      MEN1 develops after tissue inactivation of both MEN1 gene copies. Activating 
      mutations of c-RET proto-oncogene causes MEN2.
FAU - Falchetti, Alberto
AU  - Falchetti A
AD  - Surgery Unit, Department of Clinical Physiopathology, University of Florence, 
      6-50139 Florence, Italy.
FAU - Marini, Francesca
AU  - Marini F
FAU - Luzi, Ettore
AU  - Luzi E
FAU - Tonelli, Francesco
AU  - Tonelli F
FAU - Brandi, Maria Luisa
AU  - Brandi ML
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Best Pract Res Clin Rheumatol
JT  - Best practice & research. Clinical rheumatology
JID - 101121149
RN  - 0 (MAS1 protein, human)
RN  - 0 (MEN1 protein, human)
RN  - 0 (Proto-Oncogene Mas)
RN  - 0 (Proto-Oncogene Proteins)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-ret)
SB  - IM
EIN - Best Pract Res Clin Rheumatol. 2008 Dec;22(6):III. Brandt, Maria Luisa [corrected 
      to Brandi, Maria Luisa]
MH  - Adenoma/genetics
MH  - Adrenocortical Carcinoma/genetics
MH  - Gastrointestinal Neoplasms/genetics
MH  - Humans
MH  - Multiple Endocrine Neoplasia/*genetics
MH  - Pancreatic Neoplasms/genetics
MH  - Pheochromocytoma/genetics
MH  - Pituitary Neoplasms/genetics
MH  - Proto-Oncogene Mas
MH  - Proto-Oncogene Proteins/genetics
MH  - Proto-Oncogene Proteins c-ret/genetics
RF  - 68
EDAT- 2008/03/11 09:00
MHDA- 2008/08/08 09:00
CRDT- 2008/03/11 09:00
PHST- 2008/03/11 09:00 [pubmed]
PHST- 2008/08/08 09:00 [medline]
PHST- 2008/03/11 09:00 [entrez]
AID - S1521-6942(07)00129-5 [pii]
AID - 10.1016/j.berh.2007.11.010 [doi]
PST - ppublish
SO  - Best Pract Res Clin Rheumatol. 2008 Mar;22(1):149-63. doi: 
      10.1016/j.berh.2007.11.010.