PMID- 18329309
OWN - NLM
STAT- MEDLINE
DCOM- 20080806
LR  - 20131121
IS  - 1262-3636 (Print)
IS  - 1262-3636 (Linking)
VI  - 34
IP  - 2
DP  - 2008 Apr
TI  - Plasma 15-F2t isoprostane concentrations are increased during acute fructose 
      loading in type 2 diabetes.
PG  - 148-54
LID - 10.1016/j.diabet.2007.11.003 [doi]
AB  - OBJECTIVE: Fructose consumption is increasing worldwide and is likely to play a 
      role in metabolic disorders. Dietary fructose is often recommended for diabetic 
      patients, as this form of carbohydrate leads to a lower postprandial rise in 
      plasma glucose and insulin. However, fructose contributes to the generation of 
      free radicals. The aim of this work was to investigate the acute effects of a 
      fructose load in patients with type 2 diabetes mellitus (T2DM), compared with 
      healthy controls, on several metabolic oxidative biomarkers, particularly plasma 
      15-F2t isoprostanes (15-F2t isoPs). RESEARCH DESIGN AND METHODS: Six T2DM 
      patients and six healthy subjects were recruited. All patients underwent a single 
      fructose tolerance test (75 g of anhydrous fructose). Plasma 15-F2t isoPs 
      concentrations, plasma total antioxidant capacity (TAS) and thiobarbituric acid 
      reactive substances (TBARS) were measured at baseline, and at 60, 120, 180 and 
      240 min after fructose absorption. RESULTS: Baseline plasma 15-F2t isoPs 
      concentrations were significantly increased in T2DM patients compared with 
      controls (310+/-47 versus 237+/-20 pg/mL, respectively; P<0.01) and rose 
      significantly (P<0.01) to 414+/-45 pg/mL in diabetic patients. No change in TAS 
      or TBARS was observed in either group. CONCLUSION: Plasma 15-F2t isoPs are 
      increased during acute fructose loading in T2DM. Knowing the potentially 
      deleterious effect of plasma 15-F2t isoPs-in particular, vascular lesions-and in 
      light of our results, it is necessary to reconsider fructose consumption in T2DM 
      patients, as we can now show, for the first time, a possible association between 
      acute fructose loading and deleterious effects in such patients.
FAU - Faure, P
AU  - Faure P
AD  - Inserm, ERI17, laboratoire d'etude de la physiopatologie de l'hypoxie (HP2), 
      departement de biologie integree, hopital Albert-Michallon, CHU de Grenoble, 
      38042 Grenoble, France. pfaure@chu-grenoble.fr <pfaure@chu-grenoble.fr>
FAU - Polge, C
AU  - Polge C
FAU - Monneret, D
AU  - Monneret D
FAU - Favier, A
AU  - Favier A
FAU - Halimi, S
AU  - Halimi S
LA  - eng
PT  - Journal Article
DEP - 20080307
PL  - France
TA  - Diabetes Metab
JT  - Diabetes & metabolism
JID - 9607599
RN  - 0 (Blood Glucose)
RN  - 0 (Lactates)
RN  - 0 (Lipoproteins)
RN  - 0 (Triglycerides)
RN  - 27415-26-5 (8-epi-prostaglandin F2alpha)
RN  - 30237-26-4 (Fructose)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - B7IN85G1HY (Dinoprost)
SB  - IM
EIN - Diabetes Metab. 2008 Jun;34(3):297
MH  - Adult
MH  - Blood Glucose/analysis
MH  - Body Mass Index
MH  - Cholesterol/blood
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Dinoprost/*analogs & derivatives/blood
MH  - Fasting
MH  - Female
MH  - Fructose/*pharmacology
MH  - Humans
MH  - Lactates/blood
MH  - Lipoproteins/blood
MH  - Male
MH  - Middle Aged
MH  - Reference Values
MH  - Triglycerides/blood
EDAT- 2008/03/11 09:00
MHDA- 2008/08/07 09:00
CRDT- 2008/03/11 09:00
PHST- 2007/09/17 00:00 [received]
PHST- 2007/11/08 00:00 [revised]
PHST- 2007/11/19 00:00 [accepted]
PHST- 2008/03/11 09:00 [pubmed]
PHST- 2008/08/07 09:00 [medline]
PHST- 2008/03/11 09:00 [entrez]
AID - S1262-3636(08)00032-3 [pii]
AID - 10.1016/j.diabet.2007.11.003 [doi]
PST - ppublish
SO  - Diabetes Metab. 2008 Apr;34(2):148-54. doi: 10.1016/j.diabet.2007.11.003. Epub 
      2008 Mar 7.