PMID- 1832953
OWN - NLM
STAT- MEDLINE
DCOM- 19911104
LR  - 20191028
IS  - 0894-1939 (Print)
IS  - 0894-1939 (Linking)
VI  - 4
IP  - 3
DP  - 1991
TI  - Anesthetic and postoperative protocols for a canine model of reversible left 
      ventricular volume overload.
PG  - 339-46
AB  - The purpose of this study was to develop anesthetic and postoperative methods 
      that could be used in a canine model of reversible left ventricular volume 
      overload (LVVO). LVVO was created by inducing mitral regurgitation (MR) in adult 
      conditioned dogs. Using fluoroscopy, MR was induced by passing urologic grasping 
      forceps into the left ventricle through a carotid artery and rupturing one or 
      more chordae tendinea. Cardiac catheterization was performed after significant 
      cardiac dysfunction developed (3 months after creation of MR) in order to collect 
      data to confirm reduced contractile function. The MR was repaired by replacing 
      the damaged valve with a bovine pericardial xenograft. Dogs were followed with 
      sequential cardiac catheterizations to determine if the valvular replacement 
      reversed the cardiac dysfunction. To develop this model, unique anesthetic and 
      post-operative care protocols had to be instituted. In order not to exacerbate 
      the existing cardiac dysfunction, a high dose narcotic anesthetic regimen using a 
      sufentanil infusion at 9-13 microgram/kg h-1 was developed in association with 
      cardiopulmonary bypass and hypothermia for the mitral valve replacement surgery. 
      Intensive postoperative care protocols that involved major personnel and 
      pharmaceutic interventions were necessary. Using our methods 11/17 dogs survived 
      the procedure and were included in the protocol for study of mechanisms involved 
      in reversal of cardiac dysfunction.
FAU - Swindle, M M
AU  - Swindle MM
AD  - Department of Comparative Medicine, Medical University of South Carolina, 
      Charleston 29425.
FAU - Spinale, F G
AU  - Spinale FG
FAU - Smith, A C
AU  - Smith AC
FAU - Schumann, R E
AU  - Schumann RE
FAU - Green, C T
AU  - Green CT
FAU - Nakano, K
AU  - Nakano K
FAU - Kanasawa, S
AU  - Kanasawa S
FAU - Ishihara, K
AU  - Ishihara K
FAU - Zile, M R
AU  - Zile MR
FAU - Carabello, B A
AU  - Carabello BA
LA  - eng
GR  - HL38185/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Invest Surg
JT  - Journal of investigative surgery : the official journal of the Academy of 
      Surgical Research
JID - 8809255
SB  - IM
MH  - Anesthesia/*methods
MH  - Animals
MH  - Cardiomegaly/*etiology
MH  - *Disease Models, Animal
MH  - Dogs
MH  - Female
MH  - Heart Valve Prosthesis/*methods
MH  - Male
MH  - Mitral Valve Insufficiency/*surgery
MH  - *Postoperative Care
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
AID - 10.3109/08941939109141166 [doi]
PST - ppublish
SO  - J Invest Surg. 1991;4(3):339-46. doi: 10.3109/08941939109141166.