PMID- 18329817
OWN - NLM
STAT- MEDLINE
DCOM- 20080807
LR  - 20080408
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 152
IP  - 4
DP  - 2008 Apr 9
TI  - Gender-related urocortin 1 and brain-derived neurotrophic factor expression in 
      the adult human midbrain of suicide victims with major depression.
PG  - 1015-23
LID - 10.1016/j.neuroscience.2007.12.050 [doi]
AB  - In postmortem brains of patients with major depression, the expression of 
      corticotrophin-releasing factor (CRF) is enhanced and that of brain-derived 
      neurotrophic factor (BDNF) decreased. In mice over-expressing neuronal CRF (an 
      animal model for depression) the expression of urocortin 1 (Ucn1) in the 
      non-preganglionic Edinger-Westphal nucleus (npEW) is strongly down-regulated. 
      Therefore, we hypothesized that an altered activity of Ucn1 neurons in the npEW 
      would contribute to the pathogenesis of major depression. To test this hypothesis 
      we measured Ucn1 mRNA and BDNF mRNA levels in the npEW of seven male and four 
      female, drug-free suicide victims with major depression, and compared the data 
      with those obtained from 10 male and seven female individuals without 
      neurological and psychiatric disorders (controls). We show that compared with 
      controls, the Ucn1-mRNA level in npEW neurons is about 9.12 times higher in male 
      but unchanged in female suicide victims. Furthermore, BDNF mRNA expression in 
      microdissections of npEW was 3.36 times lower in male suicide victims, but 5.27 
      times higher in female victims, compared with controls. Our data also show that 
      male suicide victims had almost 11.47 times more Ucn1 and 4.26 times less BDNF 
      mRNA in the npEW than female suicide victims. We discuss the significance of 
      these data for npEW Ucn1 and BDNF, and propose that altered expressions of Ucn1 
      and BDNF in the npEW contribute to the pathogenesis of major depression and/or 
      suicidality in a gender-specific manner.
FAU - Kozicz, T
AU  - Kozicz T
AD  - Cellular Animal Physiology, Faculty of Science, EURON European Graduate School of 
      Neuroscience, Radboud University Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The 
      Netherlands. tkozicz200@yahoo.com
FAU - Tilburg-Ouwens, D
AU  - Tilburg-Ouwens D
FAU - Faludi, G
AU  - Faludi G
FAU - Palkovits, M
AU  - Palkovits M
FAU - Roubos, E
AU  - Roubos E
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080118
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - 0 (Urocortins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Analysis of Variance
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - *Depressive Disorder, Major/metabolism/pathology/psychology
MH  - Female
MH  - Humans
MH  - Male
MH  - Mesencephalon/*metabolism/pathology
MH  - Middle Aged
MH  - Neurons/metabolism
MH  - Postmortem Changes
MH  - RNA, Messenger/metabolism
MH  - *Sex Characteristics
MH  - *Suicide
MH  - Urocortins/genetics/*metabolism
EDAT- 2008/03/11 09:00
MHDA- 2008/08/08 09:00
CRDT- 2008/03/11 09:00
PHST- 2007/05/24 00:00 [received]
PHST- 2007/12/10 00:00 [revised]
PHST- 2007/12/12 00:00 [accepted]
PHST- 2008/03/11 09:00 [pubmed]
PHST- 2008/08/08 09:00 [medline]
PHST- 2008/03/11 09:00 [entrez]
AID - S0306-4522(07)01581-3 [pii]
AID - 10.1016/j.neuroscience.2007.12.050 [doi]
PST - ppublish
SO  - Neuroscience. 2008 Apr 9;152(4):1015-23. doi: 10.1016/j.neuroscience.2007.12.050. 
      Epub 2008 Jan 18.