PMID- 18330815
OWN - NLM
STAT- MEDLINE
DCOM- 20080828
LR  - 20220408
IS  - 1362-5187 (Print)
IS  - 1362-5187 (Linking)
VI  - 13 Suppl 1
DP  - 2008 Jun
TI  - Tolerability and clinical safety of Implanon.
PG  - 29-36
LID - 10.1080/13625180801960012 [doi]
AB  - OBJECTIVES: To evaluate the tolerability and clinical safety of the subdermal, 
      long-acting hormonal contraceptive Implanon. METHODS: This integrated safety 
      analysis included 11 international studies concerning Implanon (68 mg 
      etonogestrel) of which 10 had a duration of at least two years. Assessments 
      included reports of adverse events (AEs), reasons and rates of discontinuation, 
      insertion/removal complications, and the condition of the implant site. Metabolic 
      and coagulation parameters are briefly discussed to fully describe the clinical 
      safety profile. RESULTS: In total 942 women were exposed to Implanon for 24,679 
      cycles over the course of one to five years. The overall discontinuation rate was 
      32.7%; the most frequently reported reasons for discontinuation were adverse 
      events (13.9%), bleeding irregularities (10.4%), and planning pregnancy (4.1%). 
      The most commonly reported drug-related AE was headache (15.3%); however, 
      headache was reported in only 1.6% of women as a reason for discontinuation. 
      Insertion and removal times for Implanon were short with few complications, none 
      of which were major. From earlier studies it is known that treatment with 
      Implanon has little effect on metabolic and coagulation parameters. CONCLUSIONS: 
      Implanon is a well-tolerated and safe method of long-acting hormonal 
      contraception for women.
FAU - Blumenthal, Paul D
AU  - Blumenthal PD
AD  - Family Planning Services and Research, Department of Obstetrics and Gynecology, 
      Stanford University, Stanford, CA, USA. pblumen@stanford.edu
FAU - Gemzell-Danielsson, Kristina
AU  - Gemzell-Danielsson K
FAU - Marintcheva-Petrova, Maya
AU  - Marintcheva-Petrova M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Eur J Contracept Reprod Health Care
JT  - The European journal of contraception & reproductive health care : the official 
      journal of the European Society of Contraception
JID - 9712127
RN  - 0 (Contraceptive Agents, Female)
RN  - 304GTH6RNH (etonogestrel)
RN  - 81K9V7M3A3 (Desogestrel)
SB  - IM
MH  - Adult
MH  - Clinical Trials as Topic
MH  - Contraceptive Agents, Female/*adverse effects/therapeutic use
MH  - Desogestrel/*adverse effects/therapeutic use
MH  - Female
MH  - Humans
MH  - Menstruation Disturbances/chemically induced
MH  - Middle Aged
RF  - 25
EDAT- 2008/08/09 09:00
MHDA- 2008/08/30 09:00
CRDT- 2008/08/09 09:00
PHST- 2008/08/09 09:00 [pubmed]
PHST- 2008/08/30 09:00 [medline]
PHST- 2008/08/09 09:00 [entrez]
AID - 791365724 [pii]
AID - 10.1080/13625180801960012 [doi]
PST - ppublish
SO  - Eur J Contracept Reprod Health Care. 2008 Jun;13 Suppl 1:29-36. doi: 
      10.1080/13625180801960012.