PMID- 18331529
OWN - NLM
STAT- MEDLINE
DCOM- 20080807
LR  - 20131121
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 71
IP  - 5
DP  - 2008 May
TI  - Association of the HLA-G 14-bp insertion/deletion polymorphism with juvenile 
      idiopathic arthritis and rheumatoid arthritis.
PG  - 440-6
LID - 10.1111/j.1399-0039.2008.01019.x [doi]
AB  - We tested the possible association of the 14-bp polymorphism of the HLA-G gene in 
      the course of two inflammatory diseases, rheumatoid arthritis (RA) and juvenile 
      idiopathic arthritis (JIA). Patients and controls were genotyped for the 14-bp 
      polymorphism by polymerase chain reaction with specific primers for the exon 8 of 
      the human leukocyte antigen (HLA)-G gene and the amplified fragment was 
      visualized in a 6% polyacrylamide gel. A total of 106 JIA patients, 265 RA 
      patients, 356 healthy adults and 85 healthy children were genotyped for the 14-bp 
      polymorphism. Female JIA patients presented a higher frequency of the -14 bp 
      allele when compared with female healthy children (0.743 and 0.500, corrected 
      P=0.003), which reflected in the JIA group as a whole. This increased frequency 
      of the -14-bp allele was observed in all JIA subtypes. In RA patients, no 
      differences in allelic and genotypic frequencies were observed between patients 
      and controls. No correlations were observed among genotype and disease severity 
      or clinical manifestations. Our data suggest that the HLA-G -14 bp allele is 
      probably a risk factor for JIA, mainly in females. Considering the differences 
      observed in relation to gender, we suggest that hormonal differences can 
      interfere with the development of JIA. Considering the RA patients, our data 
      agree with results from the literature and highlight the differences in the 
      etiology of RA and JIA.
FAU - Veit, Tiago Degani
AU  - Veit TD
AD  - Genetics Department, Universidade Federal do Rio Grande do Sul, Porto Alegre, 
      Brazil.
FAU - Vianna, Priscilla
AU  - Vianna P
FAU - Scheibel, Iloite
AU  - Scheibel I
FAU - Brenol, Claiton Viegas
AU  - Brenol CV
FAU - Brenol, Joao Carlos Tavares
AU  - Brenol JC
FAU - Xavier, Ricardo Machado
AU  - Xavier RM
FAU - Delgado-Canedo, Andres
AU  - Delgado-Canedo A
FAU - Gutierrez, Jorge Eduardo
AU  - Gutierrez JE
FAU - Brandalize, Ana Paula Carneiro
AU  - Brandalize AP
FAU - Schuler-Faccini, Lavinia
AU  - Schuler-Faccini L
FAU - Chies, Jose Artur Bogo
AU  - Chies JA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080310
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
EIN - Tissue Antigens. 2008 Aug;72(2):185. Brenol, Claiton [corrected to Brenol, 
      Claiton Viegas]
MH  - Adolescent
MH  - Aged
MH  - Alleles
MH  - Arthritis, Juvenile/*genetics
MH  - Arthritis, Rheumatoid/*genetics
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA Antigens/*genetics
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Mutagenesis, Insertional
MH  - Polymorphism, Genetic
MH  - *Sequence Deletion
EDAT- 2008/03/12 09:00
MHDA- 2008/08/08 09:00
CRDT- 2008/03/12 09:00
PHST- 2008/03/12 09:00 [pubmed]
PHST- 2008/08/08 09:00 [medline]
PHST- 2008/03/12 09:00 [entrez]
AID - TAN1019 [pii]
AID - 10.1111/j.1399-0039.2008.01019.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2008 May;71(5):440-6. doi: 10.1111/j.1399-0039.2008.01019.x. 
      Epub 2008 Mar 10.