PMID- 18333356
OWN - NLM
STAT- MEDLINE
DCOM- 20080506
LR  - 20080312
IS  - 1220-4749 (Print)
IS  - 1220-4749 (Linking)
VI  - 45
IP  - 3
DP  - 2007
TI  - Correlation between sTNFR-I and other negative prognostic factors in patients 
      with chronic heart failure.
PG  - 243-9
AB  - Tumor necrosis factor (TNF-alpha) and plasma levels of soluble tumor necrosis 
      factor receptor I (sTNFR-I) are increased in patients with heart failure as an 
      expression of chronic inflammation, representing a negative prognostic factor. 
      Anemia and low serum lipid fraction are also negative prognostic factors, whose 
      relationship with sTNFR-I has been less studied. METHODS: The study investigated 
      54 patients with heart failure, 40 ischemic and 14 nonischemic, 35 males and 19 
      females, aged 65 +/- 10 years. Plasma sTNFR-I values (nv < 3 pg/ml) and serum 
      lipid fractions were determined in each patient and the prevalence of anemia (Ht 
      < or = 41% in men; Ht < or = 38% in women) was established. Left ventricular 
      ejection fraction (LVEF) was determined by using 2D echo. RESULTS: sTNFR-I was 
      increased in patients with heart failure--222.79 +/- 97.08 pg/ml. Anemia was 
      found in 40.74% of the patients, sTNFR-I being significantly increased in 
      patients with anemia (242.82 +/- 49.12 pg/ml) compared to patients without anemia 
      (194.9 +/- 117.3); p < 0.05. TChol (152.63 +/- 55.4 vs 177.81 +/- 38.52 mg%), 
      LDLChol (101.47 +/- 42.4 vs 113.59 +/- 28.3 mg%) and TG (96.22 +/- 59.12 vs 
      132.09 +/- 96.55 mg%) were insignificantly lower in patients with anemia. 
      Patients with anemia and low LVEF did not present higher sTNFR-I values (236.548 
      +/- 47.2) compared to patients with LVEF > 40% (245.75 +/- 52.1). A weak negative 
      correlation r = -0.31 was noted between sTNFR-I and Ht in anemic patients and 
      also between sTNFR-I and TChol (r = -0.31), LDLchol (r = -0.28), TG(r = -0.22). 
      No correlation could be established between TChol, LDLchol, TG and Ht. 
      CONCLUSION: In patients with heart failure, increased sTNFR-I as an expression of 
      chronic inflammation is correlated with both anemia and low serum lipid fractions 
      even if the exact nature of the relationship has yet to be established. There is 
      no direct correlation between anemia and low serum lipid fractions.
FAU - Pop, Dana
AU  - Pop D
AD  - Departament of Cardiology, "Iuliu Hatieganu" University of Medicine and Pharmacy 
      Cluj-Napoca, Romania. pop7dana@yahoo.com
FAU - Zdrenghea, D
AU  - Zdrenghea D
FAU - Cebanu, Mirela
AU  - Cebanu M
FAU - Borz, B
AU  - Borz B
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Rom J Intern Med
JT  - Romanian journal of internal medicine = Revue roumaine de medecine interne
JID - 9304507
RN  - 0 (Receptors, Tumor Necrosis Factor, Type I)
SB  - IM
MH  - Aged
MH  - Anemia/blood
MH  - Chronic Disease
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Heart Failure/*blood/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Receptors, Tumor Necrosis Factor, Type I/*blood
MH  - Solubility
MH  - Stroke Volume
EDAT- 2008/03/13 09:00
MHDA- 2008/05/07 09:00
CRDT- 2008/03/13 09:00
PHST- 2008/03/13 09:00 [pubmed]
PHST- 2008/05/07 09:00 [medline]
PHST- 2008/03/13 09:00 [entrez]
PST - ppublish
SO  - Rom J Intern Med. 2007;45(3):243-9.