PMID- 18333854
OWN - NLM
STAT- MEDLINE
DCOM- 20080530
LR  - 20091119
IS  - 1439-0264 (Electronic)
IS  - 0340-2096 (Linking)
VI  - 37
IP  - 2
DP  - 2008 Apr
TI  - Effects of castration on the expression of TrkB and p75NTR in the vas deferens 
      and male accessory genital glands of the rat.
PG  - 118-25
LID - 10.1111/j.1439-0264.2007.00804.x [doi]
AB  - Brain-derived neurotrophic factor (BDNF) is a growth factor belonging to the 
      family of neurotrophins. Neurotrophins exert their effects by binding to 
      corresponding receptors, which are formed by the tyrosine receptor kinases TrkA, 
      TrkB and TrkC, and the low-affinity p75NTR receptor. The role of neurotrophins in 
      the biology of male genital organs is far from clear. In particular, little is 
      known about the influence of sex hormones on the expression of neurotrophin 
      receptors. In the present study, using immunohistochemistry, we investigated the 
      distribution of TrkB and p75NTR in the vas deferens and accessory male genital 
      glands in normal and castrated rats. In normal rats, both TrkB and p75NTR 
      immunoreactivities were localized in the epithelial layer of the vas deferens and 
      prostate gland. The nerves were immunoreactive in all the examined organs. 
      Castration induced the loss of both TrkB and p75NTR immunoreactivities in the 
      epithelial layer. On the contrary, both receptors persisted or, as in the case of 
      p75NTR, increased in the nerves after castration. These results show that 
      receptors that bind BDNF are expressed in the internal male genital organs of the 
      rat and that their expression is differently regulated by androgen hormones. It 
      can be hypothesized that BDNF, via interacting with p75NTR, has a role in the 
      castration-induced regression of the sympathetic nerves.
FAU - Mirabella, N
AU  - Mirabella N
AD  - Department of Structure, Functions and Biological Technologies, University of 
      Naples Federico II, Via Veterinaria 1, I-80137, Naples, Italy. mirabell@unina.it
FAU - Squillacioti, C
AU  - Squillacioti C
FAU - De Luca, A
AU  - De Luca A
FAU - Paino, G
AU  - Paino G
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Anat Histol Embryol
JT  - Anatomia, histologia, embryologia
JID - 7704218
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptor, Nerve Growth Factor)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis
MH  - Gene Expression
MH  - Immunohistochemistry/veterinary
MH  - Male
MH  - Orchiectomy/*veterinary
MH  - Prostate/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, Nerve Growth Factor/metabolism
MH  - Receptor, trkB/metabolism
MH  - Vas Deferens/*metabolism
EDAT- 2008/03/13 09:00
MHDA- 2008/05/31 09:00
CRDT- 2008/03/13 09:00
PHST- 2008/03/13 09:00 [pubmed]
PHST- 2008/05/31 09:00 [medline]
PHST- 2008/03/13 09:00 [entrez]
AID - AHE804 [pii]
AID - 10.1111/j.1439-0264.2007.00804.x [doi]
PST - ppublish
SO  - Anat Histol Embryol. 2008 Apr;37(2):118-25. doi: 
      10.1111/j.1439-0264.2007.00804.x.