PMID- 18335322
OWN - NLM
STAT- MEDLINE
DCOM- 20080715
LR  - 20081121
IS  - 0951-3590 (Print)
IS  - 0951-3590 (Linking)
VI  - 24
IP  - 3
DP  - 2008 Mar
TI  - Serum pro-inflammatory cytokines in physiological and pre-eclamptic pregnancies.
PG  - 113-6
LID - 10.1080/09513590801895575 [doi]
AB  - BACKGROUND: Pre-eclampsia is a heterogeneous syndrome ranging from mild 
      hypertension and proteinuria to severe pre-eclampsia with complications, which 
      can also be associated with an enhanced maternal inflammatory response. METHODS: 
      Tumor necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1), interleukin-6 
      (IL-6) and interferon-gamma (IFN-gamma) were evaluated by multiplexed sandwich 
      enzyme-linked immunosorbent assay in 14 pre-eclamptic women, 57 normotensive 
      pregnant women (20 in the first, 20 in the second and 17 in the third trimester) 
      and 21 non-pregnant women. RESULTS: The concentration of serum TNF-alpha was 
      lower than the sensitivity limit of the assay in all groups. The prevalence of 
      measurable IL-1 and IL-6 values, but not that of IFN-gamma, increased 
      significantly in the second and third trimesters of pregnancy. However, the 
      percentage of subjects with higher or detectable values of pro-inflammatory 
      cytokines was statistically different between pre-eclamptic women and those in 
      the second and third trimester of physiological pregnancy. CONCLUSIONS: Results 
      of this study do not support standard screening for pro-inflammatory cytokines 
      (TNF-alpha, IL-1, IL-6 and IFN-gamma) in pre-eclampsia.
FAU - Montagnana, Martina
AU  - Montagnana M
AD  - Sezione di Chimica e Microscopia Clinica, Dipartimento di Scienze 
      Morfologico-Biomediche, Universita di Verona, Verona, Italy. 
      martina.montagnana@med.lu.se
FAU - Lippi, Giuseppe
AU  - Lippi G
FAU - Albiero, Alessandro
AU  - Albiero A
FAU - Salvagno, Gian Luca
AU  - Salvagno GL
FAU - Franchi, Massimo
AU  - Franchi M
FAU - Guidi, Gian Cesare
AU  - Guidi GC
LA  - eng
PT  - Journal Article
PL  - England
TA  - Gynecol Endocrinol
JT  - Gynecological endocrinology : the official journal of the International Society 
      of Gynecological Endocrinology
JID - 8807913
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Cytokines/*blood
MH  - Female
MH  - Gestational Age
MH  - Humans
MH  - Inflammation/*blood
MH  - Interferon-gamma/blood
MH  - Interleukin-1/blood
MH  - Interleukin-6/blood
MH  - Pre-Eclampsia/*blood
MH  - Pregnancy
MH  - Tumor Necrosis Factor-alpha/blood
EDAT- 2008/03/13 09:00
MHDA- 2008/07/17 09:00
CRDT- 2008/03/13 09:00
PHST- 2008/03/13 09:00 [pubmed]
PHST- 2008/07/17 09:00 [medline]
PHST- 2008/03/13 09:00 [entrez]
AID - 791384075 [pii]
AID - 10.1080/09513590801895575 [doi]
PST - ppublish
SO  - Gynecol Endocrinol. 2008 Mar;24(3):113-6. doi: 10.1080/09513590801895575.