PMID- 18336788
OWN - NLM
STAT- MEDLINE
DCOM- 20080624
LR  - 20220408
IS  - 0002-9394 (Print)
IS  - 0002-9394 (Linking)
VI  - 145
IP  - 6
DP  - 2008 Jun
TI  - Ocular adnexal mucosa-associated lymphoid tissue lymphoma with polyclonal 
      hypergammaglobulinemia.
PG  - 1002-1006
LID - 10.1016/j.ajo.2008.01.006 [doi]
AB  - PURPOSE: To determine the characteristics of patients with primary ocular adnexal 
      mucosa-associated lymphoid tissue (MALT) lymphoma associated with polyclonal 
      hypergammaglobulinemia. DESIGN: Case series study. METHODS: Among 81 Japanese 
      patients with primary ocular adnexal MALT lymphoma, seven patients (9%) were 
      diagnosed with polyclonal hypergammaglobulinemia. Patient clinical data included 
      a history of autoimmune disease and dissemination. Peripheral blood collected 
      from all patients was analyzed for serum levels of rheumatoid factor, soluble 
      interleukin-2 receptor (sIL-2R), and immunoglobulins at the time of diagnosis and 
      after each treatment. RESULTS: Seven patients with polyclonal 
      hypergammaglobulinemia had elevated serum levels of rheumatoid factor, sIL-2R, 
      immunoglobulin G (IgG), and immunoglobulin E (IgE) at the time of diagnosis. One 
      patient had Sjogren syndrome. Six patients (86%) had a dissemination of the MALT 
      lymphoma or lymphadenopathy at the time of diagnosis. Histopathologic examination 
      of the patients with lymphadenopathy revealed not only MALT lymphoma but also 
      secondary follicles. None of the seven patients showed improvement in serum 
      levels of IgG, rheumatoid factor, or sIL-2R in spite of complete regression of 
      the ocular lesions after radiotherapy. After administration of 
      cyclophosphamide/doxorubicin/vincristine/prednisone and/or rituximab to three 
      patients, all three showed improved serum levels of IgG, rheumatoid factor, and 
      sIL-2R. CONCLUSIONS: Patients with ocular adnexal MALT lymphoma and polyclonal 
      hypergammaglobulinemia have elevated serum levels of rheumatoid factor, sIL-2R, 
      and IgE, and high dissemination or lymphadenopathy. These unique characteristics 
      may correlate with the systemic immunologic imbalances.
FAU - Kubota, Toshinobu
AU  - Kubota T
AD  - Department of Ophthalmology, National Hospital Organization, Nagoya Medical 
      Center, 4-4-1 Sanno-maru, Naka-ku, Nagoya, Japan. ganiky@nnh.hosp.go.jp
FAU - Moritani, Suzuko
AU  - Moritani S
FAU - Yoshino, Tadashi
AU  - Yoshino T
FAU - Nagai, Hirokazu
AU  - Nagai H
FAU - Terasaki, Hiroko
AU  - Terasaki H
LA  - eng
PT  - Journal Article
DEP - 20080312
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
RN  - 0 (Immunoglobulin G)
RN  - 0 (Receptors, Interleukin-2)
RN  - 9009-79-4 (Rheumatoid Factor)
SB  - IM
CIN - Am J Ophthalmol. 2008 Jun;145(6):941-50. PMID: 18405875
MH  - Aged
MH  - Aged, 80 and over
MH  - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
MH  - Combined Modality Therapy
MH  - Conjunctival Neoplasms/*complications/pathology/therapy
MH  - Female
MH  - Humans
MH  - Hypergammaglobulinemia/blood/*complications/therapy
MH  - Immunoglobulin G/blood
MH  - Lacrimal Apparatus Diseases/*complications/pathology/therapy
MH  - Lymphoma, B-Cell, Marginal Zone/*complications/pathology/therapy
MH  - Male
MH  - Middle Aged
MH  - Orbital Neoplasms/*complications/pathology/therapy
MH  - Radiotherapy
MH  - Receptors, Interleukin-2/blood
MH  - Rheumatoid Factor/blood
EDAT- 2008/03/14 09:00
MHDA- 2008/06/25 09:00
CRDT- 2008/03/14 09:00
PHST- 2007/11/10 00:00 [received]
PHST- 2008/01/07 00:00 [revised]
PHST- 2008/01/08 00:00 [accepted]
PHST- 2008/03/14 09:00 [pubmed]
PHST- 2008/06/25 09:00 [medline]
PHST- 2008/03/14 09:00 [entrez]
AID - S0002-9394(08)00036-6 [pii]
AID - 10.1016/j.ajo.2008.01.006 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2008 Jun;145(6):1002-1006. doi: 10.1016/j.ajo.2008.01.006. Epub 
      2008 Mar 12.