PMID- 18337636
OWN - NLM
STAT- MEDLINE
DCOM- 20080710
LR  - 20080423
IS  - 1423-0224 (Electronic)
IS  - 0302-282X (Linking)
VI  - 56
IP  - 4
DP  - 2007
TI  - Blood levels of brain-derived neurotrophic factor correlate with several 
      psychopathological symptoms in anorexia nervosa patients.
PG  - 185-90
LID - 10.1159/000120623 [doi]
AB  - BACKGROUND: Evidence of a role of brain-derived neurotrophic factor (BDNF) in the 
      pathophysiology of eating disorders (ED) has been provided by association studies 
      and by murine models. BDNF plasma levels have been found altered in ED and in 
      psychiatric disorders that show comorbidity with ED. AIMS: Since the role of BDNF 
      levels in ED-related psychopathological symptoms has not been tested, we 
      investigated the correlation of BDNF plasma levels with the Symptom Checklist 90 
      Revised (SCL-90R) questionnaire in a total of 78 ED patients. METHODS: BDNF 
      levels, measured by the enzyme-linked immunoassay system, and SCL-90R 
      questionnaire, were assessed in a total of 78 ED patients. The relationship 
      between BDNF levels and SCL-90R scales was calculated using a general linear 
      model. RESULTS: BDNF plasma levels correlated with the Global Severity Index and 
      the Positive Symptom Distress Index global scales and five of the nine subscales 
      in the anorexia nervosa patients. BDNF plasma levels were able to explain, in the 
      case of the Psychoticism subscale, up to 17% of the variability (p = 0.006). 
      CONCLUSION: Our data suggest that BDNF levels could be involved in the severity 
      of the disease through the modulation of psychopathological traits that are 
      associated with the ED phenotype.
CI  - Copyright 2008 S. Karger AG, Basel.
FAU - Mercader, Josep M
AU  - Mercader JM
AD  - Genes and Disease Program, Center for Genomic Regulation (CRG), CIBER en 
      Epidemiologia y Salud Publica, Barcelona, Spain.
FAU - Fernandez-Aranda, Fernando
AU  - Fernandez-Aranda F
FAU - Gratacos, Monica
AU  - Gratacos M
FAU - Ribases, Marta
AU  - Ribases M
FAU - Badia, Anna
AU  - Badia A
FAU - Villarejo, Cynthia
AU  - Villarejo C
FAU - Solano, Raquel
AU  - Solano R
FAU - Gonzalez, Juan R
AU  - Gonzalez JR
FAU - Vallejo, Julio
AU  - Vallejo J
FAU - Estivill, Xavier
AU  - Estivill X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080313
PL  - Switzerland
TA  - Neuropsychobiology
JT  - Neuropsychobiology
JID - 7512895
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anorexia Nervosa/*blood/complications
MH  - Antisocial Personality Disorder/*blood/complications
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Enzyme-Linked Immunosorbent Assay/methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Retrospective Studies
EDAT- 2008/03/14 09:00
MHDA- 2008/07/11 09:00
CRDT- 2008/03/14 09:00
PHST- 2007/08/05 00:00 [received]
PHST- 2007/10/11 00:00 [accepted]
PHST- 2008/03/14 09:00 [pubmed]
PHST- 2008/07/11 09:00 [medline]
PHST- 2008/03/14 09:00 [entrez]
AID - 000120623 [pii]
AID - 10.1159/000120623 [doi]
PST - ppublish
SO  - Neuropsychobiology. 2007;56(4):185-90. doi: 10.1159/000120623. Epub 2008 Mar 13.