PMID- 18337661
OWN - NLM
STAT- MEDLINE
DCOM- 20080521
LR  - 20080313
IS  - 0041-1337 (Print)
IS  - 0041-1337 (Linking)
VI  - 85
IP  - 5
DP  - 2008 Mar 15
TI  - A model for human leukocyte antigen-matched donor-swap transplantation in India.
PG  - 687-92
LID - 10.1097/TP.0b013e318163827e [doi]
AB  - BACKGROUND: In developing countries such as India, extending donor-swap 
      transplantation (DSTx) to human leukocyte antigen (HLA)-mismatched patient-donor 
      pairs would increase well-matched living donor kidney transplantation rates, 
      resulting in use of less immunosuppression and less expenses, lower infective 
      morbidity, and better survival. A model for DSTx based on HLA matching is 
      presented. METHODS: Consecutive HLA class 1 antigen (A, B) tests of prospective 
      renal allograft recipients and their related donors, performed at a single center 
      in India was analyzed retrospectively using an HLA matching program to determine 
      the proportion of prospective recipients with poorly matched related donors who 
      could have benefited by DSTx based on HLA matching. RESULTS: Over the past 17.5 
      years, 2,129 prospective renal allograft recipients and 2,890 donors were tested 
      for HLA class I (A and B) antigens. Of the prospective recipients, 33% did not 
      have well-matched donors (defined as blood group compatible and sharing > or =2 
      of 4 HLA class I antigens). Among such recipients, 19.2% could have found a 
      well-matched donor-swap pair within a year at a single center. This number would 
      increase to 38% if four major national centers were involved with a shared HLA 
      registry. CONCLUSIONS: Nearly 40% of prospective recipients without well-matched 
      donors would find a donor-swap pair based on HLA matching within a year, with 
      coordination among four national centers and a shared HLA registry, increasing 
      the well-matched living donor renal transplant rates and improving transplant 
      outcomes. This finding is relevant in the context of Indian government amending 
      the Transplantation of Human Organs Act to encourage DSTx.
FAU - Basu, Gopal
AU  - Basu G
AD  - Department of Nephrology, Christian Medical College, Vellore, India.
FAU - Daniel, Dolly
AU  - Daniel D
FAU - Rajagopal, Arunachalam
AU  - Rajagopal A
FAU - Neelakantan, Nithya
AU  - Neelakantan N
FAU - John, George T
AU  - John GT
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (ABO Blood-Group System)
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
CIN - Transplantation. 2008 Mar 15;85(5):673-4. PMID: 18337658
MH  - ABO Blood-Group System
MH  - Blood Group Incompatibility
MH  - HLA Antigens/immunology
MH  - Histocompatibility Antigens Class I/*immunology
MH  - *Histocompatibility Testing
MH  - Humans
MH  - India
MH  - Kidney Transplantation/*immunology/*statistics & numerical data
MH  - Living Donors/*statistics & numerical data
MH  - Time Factors
MH  - Waiting Lists
EDAT- 2008/03/14 09:00
MHDA- 2008/05/22 09:00
CRDT- 2008/03/14 09:00
PHST- 2008/03/14 09:00 [pubmed]
PHST- 2008/05/22 09:00 [medline]
PHST- 2008/03/14 09:00 [entrez]
AID - 00007890-200803150-00007 [pii]
AID - 10.1097/TP.0b013e318163827e [doi]
PST - ppublish
SO  - Transplantation. 2008 Mar 15;85(5):687-92. doi: 10.1097/TP.0b013e318163827e.