PMID- 18337827
OWN - NLM
STAT- MEDLINE
DCOM- 20080908
LR  - 20080812
IS  - 1523-1747 (Electronic)
IS  - 0022-202X (Linking)
VI  - 128
IP  - 9
DP  - 2008 Sep
TI  - Clinicopathological characterization and genomic aberrations in subcutaneous 
      panniculitis-like T-cell lymphoma.
PG  - 2304-9
LID - 10.1038/jid.2008.6 [doi]
AB  - Subcutaneous panniculitis-like T-cell lymphomas (SPTLs) represent a rare, 
      difficult-to-diagnose, and poorly characterized subtype of cutaneous T-cell 
      lymphomas (CTCLs) affecting younger people more than the other CTCL forms. We 
      performed a thorough clinical, immunohistological, and molecular analysis of nine 
      Finnish SPTL patients. Specifically, we performed single-cell comparative genomic 
      hybridization (CGH) from laser microdissected, morphologically malignant SPTL 
      cells, as well as loss of heterozygosity (LOH) and fluorescence in situ 
      hybridization (FISH) analysis for the NAV3 (neuron navigator 3) gene. CGH 
      revealed large numbers of DNA copy number changes, the most common of which were 
      losses of chromosomes 1pter, 2pter, 10qter, 11qter, 12qter, 16, 19, 20, and 22 
      and gains of chromosomes 2q and 4q. Some of the DNA copy number aberrations in 
      SPTL, such as loss of 10q, 17p, and chromosome 19, overlap with those 
      characteristic of common forms of CTCL (mycosis fungoides (MF) and Sezary 
      syndrome (SS)), whereas 5q and 13q gains characterize SPTL. Allelic NAV3 
      aberrations (LOH or deletion by FISH), previously found in MF and SS, were 
      identified in 44% of the SPTL samples. This study demonstrates that SPTL is also 
      moleculocytogenetically a uniform entity of CTCL and supports the current World 
      Health Organization-European Organization for Research and Treatment of Cancer 
      (WHO-EORTC) classification defining SPTL as a subgroup of its own.
FAU - Hahtola, Sonja
AU  - Hahtola S
AD  - Department of Dermatology and Allergology, Helsinki University Central Hospital, 
      University of Helsinki, Helsinki, Finland. sonja.hahtola@helsinki.fi
FAU - Burghart, Elke
AU  - Burghart E
FAU - Jeskanen, Leila
AU  - Jeskanen L
FAU - Karenko, Leena
AU  - Karenko L
FAU - Abdel-Rahman, Wael M
AU  - Abdel-Rahman WM
FAU - Polzer, Bernhard
AU  - Polzer B
FAU - Kajanti, Mikael
AU  - Kajanti M
FAU - Peltomaki, Paivi
AU  - Peltomaki P
FAU - Pettersson, Tom
AU  - Pettersson T
FAU - Klein, Christoph A
AU  - Klein CA
FAU - Ranki, Annamari
AU  - Ranki A
LA  - eng
PT  - Journal Article
DEP - 20080313
PL  - United States
TA  - J Invest Dermatol
JT  - The Journal of investigative dermatology
JID - 0426720
RN  - 0 (Membrane Proteins)
RN  - 0 (NAV3 protein, human)
RN  - 0 (Nerve Tissue Proteins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Chromosome Aberrations
MH  - Chromosomes, Human, Pair 13/genetics
MH  - Chromosomes, Human, Pair 5/genetics
MH  - Female
MH  - Gene Deletion
MH  - Gene Dosage/genetics
MH  - Humans
MH  - Loss of Heterozygosity/genetics
MH  - Lymphoma, T-Cell, Cutaneous/classification/*genetics/*pathology
MH  - Male
MH  - Membrane Proteins/genetics
MH  - Middle Aged
MH  - Mycosis Fungoides/genetics
MH  - Nerve Tissue Proteins/genetics
MH  - Panniculitis/pathology
MH  - Retrospective Studies
MH  - Sezary Syndrome/genetics
MH  - Skin Neoplasms/classification/*genetics/*pathology
MH  - World Health Organization
EDAT- 2008/03/14 09:00
MHDA- 2008/09/09 09:00
CRDT- 2008/03/14 09:00
PHST- 2008/03/14 09:00 [pubmed]
PHST- 2008/09/09 09:00 [medline]
PHST- 2008/03/14 09:00 [entrez]
AID - S0022-202X(15)34011-2 [pii]
AID - 10.1038/jid.2008.6 [doi]
PST - ppublish
SO  - J Invest Dermatol. 2008 Sep;128(9):2304-9. doi: 10.1038/jid.2008.6. Epub 2008 Mar 
      13.