PMID- 18338077
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211020
IS  - 1614-0575 (Electronic)
IS  - 1613-6071 (Print)
IS  - 1613-6071 (Linking)
VI  - 4
IP  - 4
DP  - 2007 Winter
TI  - First-degree relatives of patients with type 2 diabetes mellitus and risk of 
      non-alcoholic Fatty liver disease.
PG  - 236-41
LID - 10.1900/RDS.2007.4.236 [doi]
AB  - AIMS: The aim of this study was to determine whether first-degree relatives (FDR) 
      of patients with type 2 diabetes mellitus (T2DM) are at higher risk of 
      non-alcoholic fatty liver disease (NAFLD) than healthy controls. METHODS: A total 
      of 222 FDR of consecutive patients with T2DM aged between 35 and 55 years and 202 
      healthy individuals with no family history of diabetes were investigated for 
      NAFLD. Fatty liver was diagnosed by ultrasonography using standard criteria. 
      Height, weight, fasting glucose, alanine aminotransferase (ALT), total 
      cholesterol and triglyceride were determined by routine laboratory methods. 
      RESULTS: Compared to subjects with no family history of diabetes, the age and sex 
      adjusted odds ratio (OR) of NAFLD was 1.83 (95% CI: 1.11-3.03) for FDR of 
      patients with T2DM. After further adjusting for BMI, fasting glucose, ALT, 
      asparate aminotransferase (AST), triglyceride and cholesterol, the multivariate 
      OR of prevalent NAFLD in FDR of patients with T2DM compared with individuals with 
      no family history of diabetes was 1.56 (95% CI: 0.85-2.86). CONCLUSIONS: The 
      present study suggests that the relation between FDR of patients with T2DM and 
      NAFLD is affected by the other covariates, in particular obesity, which points to 
      a more complex relationship between the diseases. It appears that obesity and 
      diabetes may independently predispose to NAFLD.
FAU - Adibi, Atoosa
AU  - Adibi A
AD  - Department of Radiology, Medical School, Isfahan University of Medical Sciences, 
      Isfahan, Iran.
FAU - Janghorbani, Mohsen
AU  - Janghorbani M
FAU - Shayganfar, Sanaz
AU  - Shayganfar S
FAU - Amini, Masoud
AU  - Amini M
LA  - eng
PT  - Journal Article
DEP - 20080210
PL  - Singapore
TA  - Rev Diabet Stud
JT  - The review of diabetic studies : RDS
JID - 101227575
PMC - PMC2270409
EDAT- 2008/03/14 09:00
MHDA- 2008/03/14 09:01
PMCR- 2009/02/10
CRDT- 2008/03/14 09:00
PHST- 2008/03/14 09:00 [pubmed]
PHST- 2008/03/14 09:01 [medline]
PHST- 2008/03/14 09:00 [entrez]
PHST- 2009/02/10 00:00 [pmc-release]
AID - 10.1900/RDS.2007.4.236 [doi]
PST - ppublish
SO  - Rev Diabet Stud. 2007 Winter;4(4):236-41. doi: 10.1900/RDS.2007.4.236. Epub 2008 
      Feb 10.