PMID- 18338255
OWN - NLM
STAT- MEDLINE
DCOM- 20081031
LR  - 20220330
IS  - 1573-6903 (Electronic)
IS  - 0364-3190 (Linking)
VI  - 33
IP  - 9
DP  - 2008 Sep
TI  - Kalirin-7, a protein enriched in postsynaptic density, is involved in ischemic 
      signal transduction.
PG  - 1789-94
LID - 10.1007/s11064-008-9631-y [doi]
AB  - Regulators of mitogen activated protein kinases (MAPK) and c-Jun 
      N-terminal/stress-activated kinase (JNK) include Rho-like small GTP-binding 
      proteins and their regulators. SynGAP and kalirin-7 are postsynaptic 
      density-enriched proteins identified through their interaction with Rho GTPases 
      and PSD-95 scaffold protein. We examined immunoreactivity of SynGAP, kalirin-7, 
      and PSD-95, phosphorylation of MAPK and JNK in control and postischemic 
      hippocampus in gerbil model of transient forebrain ischemia. In normal brain 
      higher amount of kalirin-7 but a lower amount of P-JNK was found in 
      ischemia-resistant hippocampal area: CA2-3, DG than in ischemia-vulnerable CA1. 
      After 5 min ischemia and 1 h reperfusion a decrease of P-ERK and increase of 
      P-JNK were uniformly observed in the hippocampal parts. By contrast, the amount 
      of kalirin-7 in CA2-3, DG reached 56% (P < 0.001) of control while was doubled in 
      CA1. Oppositely, the immunoreactivity of SynGAP was increased in CA2-3, DG and 
      reduced in CA1. Our data indicate that SynGAP and kalirin-7 take part in the 
      regulation of ischemic signal transduction but the mechanism does not seem 
      directly connected with the activation of MAPK and JNK.
FAU - Beresewicz, Malgorzata
AU  - Beresewicz M
AD  - Molecular Biology Unit, Mossakowski Medical Research Centre, Polish Academy of 
      Sciences, 5 Pawinskiego St., 02-106, Warsaw, Poland.
FAU - Kowalczyk, Joanna E
AU  - Kowalczyk JE
FAU - Zablocka, Barbara
AU  - Zablocka B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080313
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 0 (GTPase-Activating Proteins)
RN  - 0 (Guanine Nucleotide Exchange Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (postsynaptic density proteins)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Animals
MH  - Extracellular Signal-Regulated MAP Kinases/metabolism
MH  - GTPase-Activating Proteins/metabolism
MH  - Gerbillinae
MH  - Guanine Nucleotide Exchange Factors/genetics/*metabolism
MH  - Hippocampus/metabolism
MH  - Ischemia/*metabolism
MH  - JNK Mitogen-Activated Protein Kinases/metabolism
MH  - Nerve Tissue Proteins/genetics/*metabolism
MH  - Signal Transduction/*physiology
EDAT- 2008/03/14 09:00
MHDA- 2008/11/01 09:00
CRDT- 2008/03/14 09:00
PHST- 2007/12/17 00:00 [received]
PHST- 2008/02/14 00:00 [accepted]
PHST- 2008/03/14 09:00 [pubmed]
PHST- 2008/11/01 09:00 [medline]
PHST- 2008/03/14 09:00 [entrez]
AID - 10.1007/s11064-008-9631-y [doi]
PST - ppublish
SO  - Neurochem Res. 2008 Sep;33(9):1789-94. doi: 10.1007/s11064-008-9631-y. Epub 2008 
      Mar 13.