PMID- 18339317
OWN - NLM
STAT- MEDLINE
DCOM- 20080731
LR  - 20080506
IS  - 0009-8981 (Print)
IS  - 0009-8981 (Linking)
VI  - 392
IP  - 1-2
DP  - 2008 Jun
TI  - Relationship between CD40 ligand expression and B type natriuretic peptide levels 
      in patients with chronic heart failure.
PG  - 17-20
LID - 10.1016/j.cca.2008.02.013 [doi]
AB  - BACKGROUND: Inflammation plays a pathogenic role in the development of chronic 
      heart failure (CHF). Increasing evidence shows that CD40-CD40 ligand (CD40L) 
      interaction plays a pathogenic role in inflammatory disorders. We assessed 
      whether CD40 ligand expression was abnormal in patients with CHF. METHODS: Twenty 
      normal controls and 86 patients with CHF were investigated. The expression of 
      CD40L on platelets was analyzed by indirect-immunofluorescence flow cytometry, 
      and the soluble CD40L (sCD40L) level was determined by a commercially available 
      enzyme-linked immunosorbent assay (ELISA). B type natriuretic peptide (BNP) was 
      measured by radioimmunoassay. RESULTS: All patients with CHF showed a significant 
      increased expression of CD40L (32.3+/-13.9 MFI) on platelets and sCD40L levels 
      (20.5+/-8.6 microg/l) compared with controls(p<0.0001). CD40L expression on 
      platelets and sCD40L levels positively correlated with New York Heart Association 
      (NYHA) functional class, left ventricular ejection fraction and BNP levels in 
      CHF. CONCLUSIONS: Patients with CHF showed increased expression of CD40L system, 
      which may create a pathogenic role in the development and progression of CHF.
FAU - Yan, Jin-Chuan
AU  - Yan JC
AD  - Department of Cardiology, Affiliated Hospital of JiangSu University, Zhenjiang 
      212001, China. yanjinchuan@hotmail.com
FAU - Liu, Pei-Jing
AU  - Liu PJ
FAU - Du, Rong-Zeng
AU  - Du RZ
FAU - Liang, Yi
AU  - Liang Y
FAU - Ma, Gen-Shan
AU  - Ma GS
FAU - Zhu, Jian
AU  - Zhu J
FAU - Luo, Dan
AU  - Luo D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080216
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 147205-72-9 (CD40 Ligand)
SB  - IM
MH  - Aged
MH  - Blood Platelets/immunology/*metabolism
MH  - CD40 Ligand/*blood/immunology
MH  - Chronic Disease
MH  - Female
MH  - Heart Failure/*blood/immunology
MH  - Humans
MH  - Inflammation/immunology
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/*blood
MH  - Platelet Activation
MH  - Stroke Volume/physiology
EDAT- 2008/03/15 09:00
MHDA- 2008/08/01 09:00
CRDT- 2008/03/15 09:00
PHST- 2007/10/28 00:00 [received]
PHST- 2008/02/12 00:00 [revised]
PHST- 2008/02/12 00:00 [accepted]
PHST- 2008/03/15 09:00 [pubmed]
PHST- 2008/08/01 09:00 [medline]
PHST- 2008/03/15 09:00 [entrez]
AID - S0009-8981(08)00078-8 [pii]
AID - 10.1016/j.cca.2008.02.013 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2008 Jun;392(1-2):17-20. doi: 10.1016/j.cca.2008.02.013. Epub 
      2008 Feb 16.