PMID- 18340391
OWN - NLM
STAT- MEDLINE
DCOM- 20080522
LR  - 20211020
IS  - 1916-7075 (Electronic)
IS  - 0828-282X (Print)
IS  - 0828-282X (Linking)
VI  - 24
IP  - 3
DP  - 2008 Mar
TI  - Is elevated serum ceruloplasmin level associated with increased risk of coronary 
      artery disease?
PG  - 209-12
AB  - BACKGROUND: An imbalance between the lipid peroxidation process and antioxidative 
      protection is associated with the pathophysiology of coronary artery disease 
      (CAD). The authors aimed to determine the relationship between the contributors 
      of antioxidant protection, such as paraoxonase-1 (PON1) activity, albumin, 
      vitamin C and ceruloplasmin (CP) levels, and lipid peroxidation indicators. 
      METHODS: In the present study, the activity of PON1 was measured, together with 
      serum concentrations of a variety of lipid constituents, albumin, vitamin C and 
      CP levels, and lipid peroxidation indicators (conjugated dienes [CDs] and 
      thiobarbituric acid-reactive substances [TBARS]). Data were gathered from 26 
      nondiabetic, angiographically proven, Turkish CAD patients and 26 healthy 
      controls living in the Antalya region (Turkey). RESULTS: CAD patients had 
      significantly lower PON1 activity, high-density lipoprotein cholesterol, vitamin 
      C and albumin concentrations, and higher CP, CD and TBARS concentrations than the 
      controls. In the entire study population (n=52), serum CP levels were positively 
      correlated with TBARS and CD levels, and negatively correlated with albumin and 
      vitamin C levels, as well as with PON1 activity. On multiple logistic regression 
      analysis, risk factors associated with CAD included high CP and low albumin 
      levels. CONCLUSIONS: CAD patients and controls were matched for age and sex, and 
      high CP and low albumin levels were found to be independent risk factors for CAD. 
      The present data gathered from the study group living in the Antalya region 
      verifies that in CAD patients, CP impairs the oxidant-antioxidant balance in 
      favour of the oxidants.
FAU - Gocmen, Ayse Yesim
AU  - Gocmen AY
AD  - Department of Biochemistry, Akdeniz University, Antalya, Turkey.
FAU - Sahin, Emel
AU  - Sahin E
FAU - Semiz, Ender
AU  - Semiz E
FAU - Gumuslu, Saadet
AU  - Gumuslu S
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Can J Cardiol
JT  - The Canadian journal of cardiology
JID - 8510280
RN  - 0 (Albumins)
RN  - 0 (Lipoproteins, HDL)
RN  - EC 1.16.3.1 (Ceruloplasmin)
RN  - EC 3.1.8.1 (Aryldialkylphosphatase)
RN  - EC 3.1.8.1 (PON1 protein, human)
RN  - PQ6CK8PD0R (Ascorbic Acid)
SB  - IM
MH  - Albumins/analysis
MH  - Aryldialkylphosphatase/*blood
MH  - Ascorbic Acid/blood
MH  - Case-Control Studies
MH  - Ceruloplasmin/*analysis
MH  - Coronary Artery Disease/*blood
MH  - Female
MH  - Humans
MH  - *Lipid Peroxidation
MH  - Lipoproteins, HDL/blood
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Turkey
PMC - PMC2649635
EDAT- 2008/03/15 09:00
MHDA- 2008/05/23 09:00
PMCR- 2009/03/01
CRDT- 2008/03/15 09:00
PHST- 2008/03/15 09:00 [pubmed]
PHST- 2008/05/23 09:00 [medline]
PHST- 2008/03/15 09:00 [entrez]
PHST- 2009/03/01 00:00 [pmc-release]
AID - S0828-282X(08)70586-5 [pii]
AID - cjc24209 [pii]
AID - 10.1016/s0828-282x(08)70586-5 [doi]
PST - ppublish
SO  - Can J Cardiol. 2008 Mar;24(3):209-12. doi: 10.1016/s0828-282x(08)70586-5.