PMID- 18341492
OWN - NLM
STAT- MEDLINE
DCOM- 20080606
LR  - 20091119
IS  - 0002-9270 (Print)
IS  - 0002-9270 (Linking)
VI  - 103
IP  - 3
DP  - 2008 Mar
TI  - Molecular genetics of gastroenteropancreatic neuroendocrine tumors.
PG  - 729-32
LID - 10.1111/j.1572-0241.2007.01777.x [doi]
AB  - Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are usually sporadic; 
      however, familial (inherited) syndromes, such as the multiple endocrine neoplasia 
      1 (MEN-1) syndrome, von Hippel-Lindau (VHL) syndrome, neurofibromatosis (NF-1), 
      as well as tuberous sclerosis, may be associated with proximal intestinal and 
      pancreatic NETs. For example, 25% of gastrinoma patients have MEN-1 syndrome. 
      Over the last two decades, the genetic basis of tumorigenesis for these familial 
      syndromes has been clearly identified, providing clinicians with useful screening 
      tools for affected families. Also, over the last few years, advanced molecular 
      genetic techniques, such as comparative genomic hybridization (CGH) and loss of 
      heterozygosity (LOH) analyses, have detected some differences in genomic 
      aberrations among various types of NETs. Whether these chromosomic alterations 
      have implications in the treatment of patients and the outcome of the disease is 
      still unclear.
FAU - Toumpanakis, Christos G
AU  - Toumpanakis CG
AD  - Neuroendocrine Tumour Unit, Centre for Gastroenterology, Royal Free Hospital, 
      London, United Kingdom.
FAU - Caplin, Martyn E
AU  - Caplin ME
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Am J Gastroenterol
JT  - The American journal of gastroenterology
JID - 0421030
SB  - IM
MH  - Adenoma, Islet Cell/diagnosis/genetics
MH  - Carcinoid Tumor/diagnosis/genetics
MH  - Gastrointestinal Neoplasms/diagnosis/*genetics
MH  - Genetic Testing
MH  - Humans
MH  - Neoplastic Syndromes, Hereditary/diagnosis/genetics
MH  - Neuroendocrine Tumors/diagnosis/*genetics
MH  - Pancreatic Neoplasms/diagnosis/*genetics
RF  - 26
EDAT- 2008/03/18 09:00
MHDA- 2008/06/07 09:00
CRDT- 2008/03/18 09:00
PHST- 2008/03/18 09:00 [pubmed]
PHST- 2008/06/07 09:00 [medline]
PHST- 2008/03/18 09:00 [entrez]
AID - AJG1777 [pii]
AID - 10.1111/j.1572-0241.2007.01777.x [doi]
PST - ppublish
SO  - Am J Gastroenterol. 2008 Mar;103(3):729-32. doi: 
      10.1111/j.1572-0241.2007.01777.x.