PMID- 18342310
OWN - NLM
STAT- MEDLINE
DCOM- 20080730
LR  - 20211020
IS  - 0014-4886 (Print)
IS  - 1090-2430 (Electronic)
IS  - 0014-4886 (Linking)
VI  - 211
IP  - 1
DP  - 2008 May
TI  - Caloric restriction and age affect synaptic proteins in hippocampal CA3 and 
      spatial learning ability.
PG  - 141-9
LID - 10.1016/j.expneurol.2008.01.016 [doi]
AB  - Caloric restriction (CR) is a daily reduction of total caloric intake without a 
      decrease in micronutrients or disproportionate reduction of any one dietary 
      component. CR can increase lifespan reliably in a wide range of species and 
      appears to counteract some aspects of the aging process throughout the body. The 
      effects on the brain are less clear, but moderate CR seems to attenuate 
      age-related cognitive decline. Thus, we determined the effects of age and CR on 
      key synaptic proteins in the CA3 region of the hippocampus and whether these 
      changes were correlated with differences in behavior on a hippocampal-dependent 
      learning and memory task. We observed an overall, age-related decline in the NR1, 
      N2A and N2B subunits of the N-methyl-d-aspartate (NMDA)-type and the GluR1 and 
      GluR2 subunits of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid 
      (AMPA)-type ionotropic glutamate receptors. Interestingly, we found that CR 
      initially lowers the glutamate receptor subunit levels as compared to young AL 
      animals, and then stabilizes the levels across lifespan. Synaptophysin, a 
      presynaptic vesicle protein, showed a similar pattern. We also found that both CR 
      and ad libitum (AL) fed animals exhibited age-related cognitive decline on the 
      Morris water maze task. However, AL animals declined between young and middle 
      age, and between middle age and old, whereas CR rats only declined between young 
      and middle age. Thus, the decrease in key synaptic proteins in CA3 and cognitive 
      decline occurring across lifespan are stabilized by CR. This age-related decrease 
      and CR-induced stabilization are likely to affect CA3 synaptic plasticity and, as 
      a result, hippocampal function.
FAU - Adams, Michelle M
AU  - Adams MM
AD  - Department of Neurobiology and Anatomy, Wake Forest University Health Sciences, 
      Winston-Salem, NC 27157, USA. miadams@wfubmc.edu
FAU - Shi, Lei
AU  - Shi L
FAU - Linville, M Constance
AU  - Linville MC
FAU - Forbes, M Elizabeth
AU  - Forbes ME
FAU - Long, Ashley B
AU  - Long AB
FAU - Bennett, Colleen
AU  - Bennett C
FAU - Newton, Isabel G
AU  - Newton IG
FAU - Carter, Christy S
AU  - Carter CS
FAU - Sonntag, William E
AU  - Sonntag WE
FAU - Riddle, David R
AU  - Riddle DR
FAU - Brunso-Bechtold, Judy K
AU  - Brunso-Bechtold JK
LA  - eng
GR  - AG 11370/AG/NIA NIH HHS/United States
GR  - R01 AG019886-05/AG/NIA NIH HHS/United States
GR  - P30 AG028740/AG/NIA NIH HHS/United States
GR  - P01 AG011370/AG/NIA NIH HHS/United States
GR  - K01 AG027828-03/AG/NIA NIH HHS/United States
GR  - AG 019886/AG/NIA NIH HHS/United States
GR  - R01 AG026607/AG/NIA NIH HHS/United States
GR  - P01 AG011370-030003/AG/NIA NIH HHS/United States
GR  - R01 AG019886/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20080208
PL  - United States
TA  - Exp Neurol
JT  - Experimental neurology
JID - 0370712
RN  - 0 (Receptors, Glutamate)
SB  - IM
MH  - Age Factors
MH  - Aging/*physiology
MH  - Analysis of Variance
MH  - Animals
MH  - Behavior, Animal
MH  - *Caloric Restriction
MH  - Gene Expression Regulation
MH  - Hippocampus/*physiology
MH  - Learning/*physiology
MH  - Male
MH  - Maze Learning
MH  - Rats
MH  - Receptors, Glutamate/classification/*metabolism
MH  - Space Perception/*physiology
MH  - Swimming
PMC - PMC2805131
MID - NIHMS50609
EDAT- 2008/03/18 09:00
MHDA- 2008/07/31 09:00
PMCR- 2010/01/12
CRDT- 2008/03/18 09:00
PHST- 2007/10/17 00:00 [received]
PHST- 2008/01/17 00:00 [revised]
PHST- 2008/01/21 00:00 [accepted]
PHST- 2008/03/18 09:00 [pubmed]
PHST- 2008/07/31 09:00 [medline]
PHST- 2008/03/18 09:00 [entrez]
PHST- 2010/01/12 00:00 [pmc-release]
AID - S0014-4886(08)00033-2 [pii]
AID - 10.1016/j.expneurol.2008.01.016 [doi]
PST - ppublish
SO  - Exp Neurol. 2008 May;211(1):141-9. doi: 10.1016/j.expneurol.2008.01.016. Epub 
      2008 Feb 8.