PMID- 18342317
OWN - NLM
STAT- MEDLINE
DCOM- 20100126
LR  - 20211020
IS  - 1879-1484 (Electronic)
IS  - 0021-9150 (Print)
IS  - 0021-9150 (Linking)
VI  - 201
IP  - 1
DP  - 2008 Nov
TI  - Matrix metalloproteinase-3 (MMP3) and MMP9 genes and risk of myocardial 
      infarction, ischemic stroke, and hemorrhagic stroke.
PG  - 130-7
LID - 10.1016/j.atherosclerosis.2008.01.003 [doi]
AB  - OBJECTIVE: We assessed the association of genetic variation in MMP3 and MMP9 with 
      risk of myocardial infarction and stroke. METHODS: A case-control study was 
      conducted among members of Group Health (GH), a large-integrated health care 
      delivery system. Case subjects with incident non-fatal myocardial infarction 
      (n=854), ischemic stroke (n=367), and hemorrhagic stroke (n=66) were identified 
      and validated. A matched control group was selected from among GH members without 
      myocardial infarction or stroke (n=2696). Haplotype-tagging sets of 
      single-nucleotide polymorphisms (SNPs) in MMP3 and MMP9 were genotyped. RESULTS: 
      MMP3 haplotype 2 was associated with reduced risk of myocardial infarction 
      (adjusted odds ratio (OR) per copy=0.80, 95% confidence interval 0.66, 0.98) and 
      increased risk of hemorrhagic stroke (OR=1.69, 95% confidence interval 1.05, 
      2.75). Results for MMP3 haplotype 2 and ischemic stroke resembled those for 
      myocardial infarction but did not achieve statistical significance (OR=0.85, 95% 
      confidence interval 0.64, 1.12). No individual SNP identified MMP3 haplotype 2, 
      and none of the individual MMP3 SNPs were associated with myocardial infarction 
      or stroke. MMP9 haplotypes or SNPs were not associated with myocardial infarction 
      or stroke. CONCLUSIONS: MMP3 haplotype may predict both cardiac events and 
      stroke.
FAU - Kaplan, Robert C
AU  - Kaplan RC
AD  - Department of Epidemiology and Population Health, Albert Einstein College of 
      Medicine, Belfer Building, Room 1306C, 1300 Morris Park Avenue, Bronx, NY, United 
      States. rkaplan@aecom.yu.edu
FAU - Smith, Nicholas L
AU  - Smith NL
FAU - Zucker, Stanley
AU  - Zucker S
FAU - Heckbert, Susan R
AU  - Heckbert SR
FAU - Rice, Kenneth
AU  - Rice K
FAU - Psaty, Bruce M
AU  - Psaty BM
LA  - eng
GR  - R01 HL043201/HL/NHLBI NIH HHS/United States
GR  - R01 HL043201-09A1/HL/NHLBI NIH HHS/United States
PT  - Journal Article
DEP - 20080314
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brain Ischemia/enzymology/epidemiology/genetics
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Haplotypes
MH  - Humans
MH  - Incidence
MH  - Intracranial Hemorrhages/enzymology/epidemiology/genetics
MH  - Male
MH  - Matrix Metalloproteinase 3/*genetics
MH  - Matrix Metalloproteinase 9/*genetics
MH  - Middle Aged
MH  - Myocardial Infarction/enzymology/*epidemiology/*genetics
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Stroke/enzymology/*epidemiology/*genetics
PMC - PMC3077423
MID - NIHMS78308
EDAT- 2008/03/18 09:00
MHDA- 2010/01/27 06:00
PMCR- 2011/04/14
CRDT- 2008/03/18 09:00
PHST- 2007/11/05 00:00 [received]
PHST- 2007/12/28 00:00 [revised]
PHST- 2008/01/23 00:00 [accepted]
PHST- 2008/03/18 09:00 [pubmed]
PHST- 2010/01/27 06:00 [medline]
PHST- 2008/03/18 09:00 [entrez]
PHST- 2011/04/14 00:00 [pmc-release]
AID - S0021-9150(08)00056-7 [pii]
AID - 10.1016/j.atherosclerosis.2008.01.003 [doi]
PST - ppublish
SO  - Atherosclerosis. 2008 Nov;201(1):130-7. doi: 
      10.1016/j.atherosclerosis.2008.01.003. Epub 2008 Mar 14.