PMID- 18342945
OWN - NLM
STAT- MEDLINE
DCOM- 20080825
LR  - 20131121
IS  - 0161-813X (Print)
IS  - 0161-813X (Linking)
VI  - 29
IP  - 3
DP  - 2008 May
TI  - Gender differences in susceptibility to kainic acid-induced neurodegeneration in 
      aged C57BL/6 mice.
PG  - 406-12
LID - 10.1016/j.neuro.2008.01.006 [doi]
AB  - Some epidemiological studies concerning gender differences in Alzheimer's disease 
      (AD) support the higher prevalence and incidence of AD in women, while most 
      studies using animal models of aging have included only male subjects. It is 
      still uncommon for aged males and females to be compared in the same study. In 
      the present study, we investigated how age and gender influence the excitotoxic 
      neurodegeneration by treating C57BL/6 mice (aged females and males as well as 
      adult females and males) with kainic acid (KA) intranasally. Clinical signs, 
      behavioural changes, pathological changes and astrocyte proliferation were 
      tested; and the levels of brain-derived neurotrophic factor (BDNF) and nerve 
      growth factor (NGF) were measured after KA treatment. The results showed that 
      aged female mice were more sensitive to KA-induced excitotoxicity as demonstrated 
      by severer seizure activity, increased locomotion and rearing in open-field test, 
      prominent hippocampal neuronal damage, enhanced astrocyte proliferation compared 
      with aged males, adult females and adult male mice. In addition, higher BDNF 
      level in hippocampus of aged female mice was observed. These results denote the 
      disparity of aging and gender in KA-induced hippocampal neurodegeneration and 
      aged female mice are more sensitive to the excitotoxicity.
FAU - Zhang, Xing-Mei
AU  - Zhang XM
AD  - Department of Neurobiology, Care Sciences and Society, Karolinska Institute, 
      Stockholm, Sweden.
FAU - Zhu, Shun-Wei
AU  - Zhu SW
FAU - Duan, Rui-Sheng
AU  - Duan RS
FAU - Mohammed, Abdul H
AU  - Mohammed AH
FAU - Winblad, Bengt
AU  - Winblad B
FAU - Zhu, Jie
AU  - Zhu J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080208
PL  - Netherlands
TA  - Neurotoxicology
JT  - Neurotoxicology
JID - 7905589
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Excitatory Amino Acid Agonists)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Nerve Growth Factors)
RN  - SIV03811UC (Kainic Acid)
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Astrocytes/drug effects
MH  - Behavior, Animal/drug effects
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cell Proliferation/drug effects
MH  - Cerebral Cortex/pathology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Excitatory Amino Acid Agonists/*toxicity
MH  - Female
MH  - Glial Fibrillary Acidic Protein/metabolism
MH  - Hippocampus/pathology
MH  - Immunohistochemistry
MH  - Kainic Acid/*toxicity
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Motor Activity/drug effects
MH  - Nerve Degeneration/*chemically induced/pathology
MH  - Nerve Growth Factors/metabolism
MH  - Seizures/chemically induced/pathology
MH  - Sex Characteristics
EDAT- 2008/03/18 09:00
MHDA- 2008/08/30 09:00
CRDT- 2008/03/18 09:00
PHST- 2007/10/30 00:00 [received]
PHST- 2008/01/10 00:00 [revised]
PHST- 2008/01/29 00:00 [accepted]
PHST- 2008/03/18 09:00 [pubmed]
PHST- 2008/08/30 09:00 [medline]
PHST- 2008/03/18 09:00 [entrez]
AID - S0161-813X(08)00011-9 [pii]
AID - 10.1016/j.neuro.2008.01.006 [doi]
PST - ppublish
SO  - Neurotoxicology. 2008 May;29(3):406-12. doi: 10.1016/j.neuro.2008.01.006. Epub 
      2008 Feb 8.