PMID- 18346054
OWN - NLM
STAT- MEDLINE
DCOM- 20080717
LR  - 20181217
IS  - 1742-7843 (Electronic)
IS  - 1742-7835 (Linking)
VI  - 102
IP  - 5
DP  - 2008 May
TI  - Insulin-secretagogue activity of p-methoxycinnamic acid in rats, perfused rat 
      pancreas and pancreatic beta-cell line.
PG  - 476-82
LID - 10.1111/j.1742-7843.2008.00218.x [doi]
AB  - This study investigated the effect of p-methoxycinnamic acid (p-MCA) on plasma 
      glucose and insulin concentrations in normal and streptozotocin-induced diabetic 
      rats. In both fasting and glucose-loading conditions, an oral administration of 
      p-MCA (40-100 mg/kg) significantly decreased plasma glucose and also increased 
      plasma insulin concentrations in both normal and diabetic rats. The onset of the 
      p-MCA-induced antihyperglycaemia/hypoglycaemia was observed at 1 hr after 
      administration. In perfused rat pancreas, p-MCA (10-100 microM) stimulated 
      insulin secretion about 1.4- and 3.1-fold of basal-control group. In addition, 
      p-MCA (10 microM) enhanced glucose-induced insulin secretion. Moreover, p-MCA 
      stimulated insulin secretion and increased intracellular Ca(2+) concentration 
      ([Ca(2+)](i)) in insulinoma-1 cells. Taken together, our findings suggested that 
      p-MCA exerted antihyperglycaemic/hypoglycaemic effect by stimulating insulin 
      secretion from pancreas and could be developed into a new potential for 
      therapeutic agent used in type 2 diabetic patients.
FAU - Yibchok-anun, Sirintorn
AU  - Yibchok-anun S
AD  - Department of Pharmacology, Faculty of Veterinary Science, Chulalongkorn 
      University, Bangkok, Thailand. sirintorn.y@chula.ac.th
FAU - Adisakwattana, Sirichai
AU  - Adisakwattana S
FAU - Moonsan, Preecha
AU  - Moonsan P
FAU - Hsu, Walter H
AU  - Hsu WH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080316
PL  - England
TA  - Basic Clin Pharmacol Toxicol
JT  - Basic & clinical pharmacology & toxicology
JID - 101208422
RN  - 0 (Blood Glucose)
RN  - 0 (Cinnamates)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
RN  - 5W494URQ81 (Streptozocin)
RN  - 6G4ML8401A (4-methoxycinnamic acid)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Calcium/metabolism
MH  - Cell Line, Tumor
MH  - Cinnamates/*pharmacology/therapeutic use
MH  - Diabetes Mellitus, Experimental/drug therapy
MH  - Glucose Tolerance Test
MH  - Hypoglycemic Agents/*pharmacology/therapeutic use
MH  - In Vitro Techniques
MH  - Insulin/*blood/metabolism
MH  - Insulin Secretion
MH  - Insulin-Secreting Cells/cytology/drug effects/metabolism
MH  - Intracellular Space/metabolism
MH  - Male
MH  - Pancreas/*drug effects/metabolism
MH  - Perfusion
MH  - Rats
MH  - Rats, Wistar
MH  - Streptozocin
EDAT- 2008/03/19 09:00
MHDA- 2008/07/18 09:00
CRDT- 2008/03/19 09:00
PHST- 2008/03/19 09:00 [pubmed]
PHST- 2008/07/18 09:00 [medline]
PHST- 2008/03/19 09:00 [entrez]
AID - PTO218 [pii]
AID - 10.1111/j.1742-7843.2008.00218.x [doi]
PST - ppublish
SO  - Basic Clin Pharmacol Toxicol. 2008 May;102(5):476-82. doi: 
      10.1111/j.1742-7843.2008.00218.x. Epub 2008 Mar 16.