PMID- 18346164
OWN - NLM
STAT- MEDLINE
DCOM- 20080716
LR  - 20221207
IS  - 1464-5491 (Electronic)
IS  - 0742-3071 (Linking)
VI  - 25
IP  - 4
DP  - 2008 Apr
TI  - Fatty liver is an independent risk factor for the development of Type 2 diabetes 
      in Korean adults.
PG  - 476-81
LID - 10.1111/j.1464-5491.2008.02410.x [doi]
AB  - AIMS: To investigate whether fatty liver per se is an independent risk factor of 
      incident type 2 diabetes mellitus (T2DM) in Koreans. METHODS: We examined the 
      clinical and laboratory data of 5372 non-diabetic participants (3670 men and 1702 
      women; age 46.8 +/- 8.4 years, range 20-79 years) who underwent voluntary medical 
      check-ups in 2000 and follow-up examinations in 2005. RESULTS: Two hundred and 
      thirty-three participants (4.3%) developed T2DM after 5 years. Univariate 
      analysis showed that the development of diabetes was associated with: male sex; 
      family history of diabetes; smoking; older age; higher body mass index (BMI), 
      systolic and diastolic blood pressure, fasting plasma glucose (FPG), hepatic 
      enzymes, total cholesterol and triglycerides; lower HDL cholesterol; and the 
      presence of fatty liver on ultrasonography at baseline. In multiple logistic 
      regression models, after adjusting for age, sex and alcohol consumption, patients 
      with fatty liver were at significantly higher risk of developing T2DM compared to 
      those without fatty liver [relative risk (RR) 3.92, 95% confidence interval (CI) 
      2.89-5.31]. After further adjustment for smoking, BMI, triglycerides, HDL 
      cholesterol, FPG, alanine aminotransferase and ultrasonographer, fatty liver 
      remained significantly associated with the development of T2DM (RR 1.51, 95% CI 
      1.04-2.20). Patients with moderate to severe fatty liver had higher risk ratios 
      than patients with mild fatty liver. Exclusion of frequent drinkers did not 
      attenuate the association. CONCLUSIONS: Fatty liver on ultrasonography is 
      associated with the development of T2DM, independently of classical risk factors, 
      in Korean adults.
FAU - Kim, C-H
AU  - Kim CH
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Soonchunhyang University College of Medicine, Bucheon, Korea.
FAU - Park, J-Y
AU  - Park JY
FAU - Lee, K-U
AU  - Lee KU
FAU - Kim, J-H
AU  - Kim JH
FAU - Kim, H-K
AU  - Kim HK
LA  - eng
PT  - Journal Article
DEP - 20080313
PL  - England
TA  - Diabet Med
JT  - Diabetic medicine : a journal of the British Diabetic Association
JID - 8500858
RN  - 0 (Blood Glucose)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Asian People/ethnology
MH  - Blood Glucose/*metabolism
MH  - Diabetes Mellitus, Type 2/*ethnology/metabolism/prevention & control
MH  - Fatty Liver/*ethnology/metabolism
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Triglycerides/metabolism
EDAT- 2008/03/19 09:00
MHDA- 2008/07/17 09:00
CRDT- 2008/03/19 09:00
PHST- 2008/03/19 09:00 [pubmed]
PHST- 2008/07/17 09:00 [medline]
PHST- 2008/03/19 09:00 [entrez]
AID - DME2410 [pii]
AID - 10.1111/j.1464-5491.2008.02410.x [doi]
PST - ppublish
SO  - Diabet Med. 2008 Apr;25(4):476-81. doi: 10.1111/j.1464-5491.2008.02410.x. Epub 
      2008 Mar 13.