PMID- 18346322
OWN - NLM
STAT- MEDLINE
DCOM- 20080711
LR  - 20161124
IS  - 0578-1426 (Print)
IS  - 0578-1426 (Linking)
VI  - 47
IP  - 1
DP  - 2008 Jan
TI  - [Associations between the plasma inflammatory markers and plaque morphologies of 
      coronary artery lesions].
PG  - 27-30
AB  - OBJECTIVE: To evaluate the vulnerability of coronary artery plaque with coronary 
      angiography (CAG), intravascular ultrasound (IVUS) and the levels of plasma 
      inflammatory markers. METHODS: 58 consecutive patients with lesion of a single 
      blood vessel demonstrated successfully by CAG were randomly divided into 3 groups 
      based on the angiographic morphology of the the lesions: type I lesion group (n = 
      16), type II lesion group (n = 25), type III lesion group (n = 17). Meantime, a 
      control group of stable angina (n = 17) was established. A subgroup of 28 
      patients (including 18 acute coronary syndrome (ACS) patients and 10 stable 
      angina control patients) who underwent IVUS study were analyzed. Then the plasma 
      levels of high sensitivity CRP (hs-CRP), matrix metalloproteinase (MMP, including 
      MMP-2 and MMP-9), CD(40) ligand (CD(40)L) and pregnancy associated plasma 
      protein-A (PAPP-A) were measured with ELISA. Analyses were performed by 
      statistical package SPSS 11.0. RESULTS: The plasma levels of MMP-2, MMP-9 and 
      PAPP-A in type II lesion group were significantly higher than the other groups (P 
      < 0.05, 0.05, 0.001, respectively). In type II lesion group, linear correlation 
      analysis manifested significantly positive correlation between levels of hs-CRP 
      and MMP-2 (r = 0.508); MMP-2 and MMP-9, CD(40)L, PAPP-A (r = 0.647, 0.704, 0.751, 
      respectively); MMP-9 and CD(40)L, PAPP-A (r = 0.491, 0.639, respectively); 
      CD(40)L and PAPP-A (r = 0.896). IVUS subgroup analysis showed that the area of 
      plaques and plaques burden in culprit lesion, the incidence of high-risk plaques, 
      remodeling index (RI) and positive remodeling percentage in ACS patients were 
      significantly greater than those in the control group (P = 0.000, 0.037, 0.028, 
      0.015, 0.040, respectively). Compared with the control group, the plasma levels 
      of hs-CRP, MMP-2, MMP-9 and PAPP-A were markedly elevated (P = 0.033, 0.000, 
      0.000, 0.027, respectively). CONCLUSIONS: CAG and IVUS combined with the study on 
      plasma levels of inflammation mediators were helpful in judging the vulnerability 
      of coronary artery plaques.
FAU - Wang, Xian
AU  - Wang X
AD  - Heart Centre of Beijing Army General Hospital, Beijing 100700, China. 
      wx0515@hotmail.com
FAU - Hu, Da-Yi
AU  - Hu DY
FAU - Yang, Shi-Wei
AU  - Yang SW
FAU - Zhang, Jian
AU  - Zhang J
FAU - Tan, Chen
AU  - Tan C
FAU - Zhang, Shou-Yan
AU  - Zhang SY
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Nei Ke Za Zhi
JT  - Zhonghua nei ke za zhi
JID - 16210490R
RN  - 0 (Inflammation Mediators)
RN  - 147205-72-9 (CD40 Ligand)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 3.4.24.- (Pregnancy-Associated Plasma Protein-A)
RN  - EC 3.4.24.24 (MMP2 protein, human)
RN  - EC 3.4.24.24 (Matrix Metalloproteinase 2)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Aged
MH  - C-Reactive Protein/metabolism
MH  - CD40 Ligand/blood
MH  - Coronary Artery Disease/*blood/diagnostic imaging/*pathology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Inflammation Mediators/*blood
MH  - Male
MH  - Matrix Metalloproteinase 2/blood
MH  - Matrix Metalloproteinase 9/blood
MH  - Middle Aged
MH  - Pregnancy-Associated Plasma Protein-A/metabolism
MH  - Ultrasonography, Interventional/methods
EDAT- 2008/03/19 09:00
MHDA- 2008/07/12 09:00
CRDT- 2008/03/19 09:00
PHST- 2008/03/19 09:00 [pubmed]
PHST- 2008/07/12 09:00 [medline]
PHST- 2008/03/19 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Nei Ke Za Zhi. 2008 Jan;47(1):27-30.