PMID- 18346859
OWN - NLM
STAT- MEDLINE
DCOM- 20080702
LR  - 20131121
IS  - 0378-8741 (Print)
IS  - 0378-8741 (Linking)
VI  - 117
IP  - 1
DP  - 2008 Apr 17
TI  - Baccharis trimera: effect on hematological and biochemical parameters and 
      hepatorenal evaluation in pregnant rats.
PG  - 28-33
LID - 10.1016/j.jep.2007.12.020 [doi]
AB  - AIM OF THE STUDY: This investigation evaluated the effect of a hydroethanolic 
      extract of Baccharis trimera on pregnant Wistar rats, once the plant is 
      well-known consumed in pregnancy and little is known on its potentially toxic 
      effects on pregnant women. MATERIAL AND METHODS: Thirty-five female rats were 
      distributed into three groups. Those in treatments 1 and 2 were given 8.4 mg/kg 
      of the extract orally from gestational day (GD) 1 to 19 and from GD 6 to 15, 
      respectively, whereas those in the control group received distilled water orally 
      from GD 1 to 19. Body weights were recorded on GD 1, 6, 15, and 20. On GD 20 
      animals were anesthetized, blood samples were collected and maternal livers, 
      kidneys, and spleens were weighed and processed for histological studies. 
      RESULTS: No clinical signs of maternal toxicity and no changes in hematological 
      parameters were observed. Urea levels and kidney weights differed significantly 
      between animals receiving treatment 1 and controls. Histopathological alterations 
      were found in kidneys and livers in both treatment groups. CONCLUSIONS: The 
      hydroethanolic extract of Baccharis trimera administered to pregnant rats at 8.4 
      mg/kg was toxic to maternal kidney and liver cells, although such alterations are 
      reversible once administration is discontinued.
FAU - Grance, Simone Reschke Mendes
AU  - Grance SR
AD  - Program in Animal Science, Universidade Federal de Mato Grosso do Sul (UFMS), Cx. 
      Postal 549, Campo Grande, MS 79070-900, Brazil. simonermg@yahoo.com.br
FAU - Teixeira, Maria Araujo
AU  - Teixeira MA
FAU - Leite, Roseana Silveira
AU  - Leite RS
FAU - Guimaraes, Euripedes Batista
AU  - Guimaraes EB
FAU - de Siqueira, Joao Maximo
AU  - de Siqueira JM
FAU - de Oliveira Filiu, Wander Fernando
AU  - de Oliveira Filiu WF
FAU - de Souza Vasconcelos, Simone Bertozi
AU  - de Souza Vasconcelos SB
FAU - do Carmo Vieira, Maria
AU  - do Carmo Vieira M
LA  - eng
PT  - Journal Article
DEP - 20080119
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Plant Extracts)
RN  - 8W8T17847W (Urea)
SB  - IM
MH  - Animals
MH  - Baccharis/*toxicity
MH  - Blood Cells/drug effects
MH  - Female
MH  - Kidney/*drug effects/pathology
MH  - Liver/*drug effects/pathology
MH  - Plant Extracts/toxicity
MH  - Pregnancy
MH  - Rats
MH  - Rats, Wistar
MH  - Urea/blood
EDAT- 2008/03/19 09:00
MHDA- 2008/07/03 09:00
CRDT- 2008/03/19 09:00
PHST- 2007/07/02 00:00 [received]
PHST- 2007/12/24 00:00 [revised]
PHST- 2007/12/31 00:00 [accepted]
PHST- 2008/03/19 09:00 [pubmed]
PHST- 2008/07/03 09:00 [medline]
PHST- 2008/03/19 09:00 [entrez]
AID - S0378-8741(08)00005-6 [pii]
AID - 10.1016/j.jep.2007.12.020 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2008 Apr 17;117(1):28-33. doi: 10.1016/j.jep.2007.12.020. Epub 
      2008 Jan 19.