PMID- 18346907
OWN - NLM
STAT- MEDLINE
DCOM- 20080904
LR  - 20111117
IS  - 1096-0023 (Electronic)
IS  - 1043-4666 (Linking)
VI  - 42
IP  - 1
DP  - 2008 Apr
TI  - The simultaneous presence of IL-1B and TNFA two-positions risk haplotypes 
      enhances the susceptibility for celiac disease.
PG  - 48-54
LID - 10.1016/j.cyto.2008.01.015 [doi]
AB  - To assess the joint contribution of interleukin 1 beta (IL-1B) and tumor necrosis 
      factor alpha (TNFalpha) to the genetic risk of developing celiac disease (CD), we 
      analyzed four biallelic polymorphisms of TNFA and IL-1B genes in 228 patients and 
      244 healthy controls. The individual contribution of TNFA -308A and IL-1B -511C 
      alleles was weak (OR 1.47 and 1.66, respectively) and was null for TNFA -238 A/G 
      and IL-1B +3953 C/T single nucleotide polymorphisms (SNPs). Due to the potential 
      linkage disequilibrium between TNFA, human leukocyte antigen (HLA) -DQA1 and 
      HLA-DQB1 genes, only individuals carrying DQ2 antigen (DQ2-positive) were 
      considered to perform haplotype analyses. Two-position risk haplotypes were first 
      defined by the combined presence of -511C and +3953T alleles for IL-1B (OR 9.402) 
      or -308A and -238A alleles for TNFA (OR 15.389). The TNFA/IL-1B combined 
      haplotype-stratified association analysis showed that the simultaneous presence 
      of TNFA risk and IL-1B non-risk haplotypes (OR 13.32) but not TNFA non-risk and 
      IL-1B risk haplotypes (OR 0.71) is associated with CD. Interestingly, our data 
      suggest that the coexistence of both risk haplotypes seems to work 
      synergistically (OR 29.59), which enhances the risk of developing CD.
FAU - Chernavsky, Alejandra Claudia
AU  - Chernavsky AC
AD  - Immunogenetic Laboratory, Hospital de Clinicas Jose de San Martin, Universidad de 
      Buenos Aires, Av. Cordoba 2351, 1120 Buenos Aires, Argentina. 
      accher@fibertel.com.ar
FAU - Paez, Maria Carolina
AU  - Paez MC
FAU - Periolo, Natalia
AU  - Periolo N
FAU - Correa, Paula
AU  - Correa P
FAU - Guillen, Laura
AU  - Guillen L
FAU - Niveloni, Sonia Isabel
AU  - Niveloni SI
FAU - Maurino, Eduardo
AU  - Maurino E
FAU - Bai, Julio Cesar
AU  - Bai JC
FAU - Anaya, Juan-Manuel
AU  - Anaya JM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080317
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - *Celiac Disease/genetics/immunology
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-DQ Antigens/genetics/immunology
MH  - HLA-DQ alpha-Chains
MH  - HLA-DQ beta-Chains
MH  - *Haplotypes
MH  - Humans
MH  - Interleukin-1beta/*genetics/metabolism
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Sequence Analysis, DNA
MH  - Tumor Necrosis Factor-alpha/*genetics/metabolism
EDAT- 2008/03/19 09:00
MHDA- 2008/09/05 09:00
CRDT- 2008/03/19 09:00
PHST- 2007/09/27 00:00 [received]
PHST- 2007/12/18 00:00 [revised]
PHST- 2008/01/30 00:00 [accepted]
PHST- 2008/03/19 09:00 [pubmed]
PHST- 2008/09/05 09:00 [medline]
PHST- 2008/03/19 09:00 [entrez]
AID - S1043-4666(08)00033-1 [pii]
AID - 10.1016/j.cyto.2008.01.015 [doi]
PST - ppublish
SO  - Cytokine. 2008 Apr;42(1):48-54. doi: 10.1016/j.cyto.2008.01.015. Epub 2008 Mar 
      17.