PMID- 18347687
OWN - NLM
STAT- MEDLINE
DCOM- 20080825
LR  - 20160513
IS  - 1715-5312 (Print)
IS  - 1715-5312 (Linking)
VI  - 33
IP  - 2
DP  - 2008 Apr
TI  - Adding carbohydrate to a high-fat meal blunts postprandial lipemia in women and 
      reduces meal-derived fatty acids in systemic circulation.
PG  - 315-25
LID - 10.1139/H07-190 [doi]
AB  - The lipemic response to a meal is an important independent risk factor for the 
      development of cardiovascular disease. The purpose of this study was to determine 
      the effect of adding carbohydrate (CHO) to a fat meal on the bioavailability of 
      ingested fat in different blood lipid fractions in men and women. On two separate 
      occasions, 18 healthy adults (9 women, 9 men) ate either a high-fat meal (0.7 
      grams fat per kilogram) (FAT), or the same meal with added CHO (1 gram CHO per 
      kilogram) (FAT+CHO) in the morning after a 12 h fast. Both meals were 
      supplemented with [13C]-palmitate (25 mg.kg(-1)). Plasma concentrations of 
      triglyceride (TG), fatty acids, insulin, and glucose were measured in blood 
      samples taken hourly from 0 to 8 h after the meal. In addition, we measured TG 
      concentrations in chylomicron (CHYLO-TG) and in very-low-density lipoprotein 
      (VLDL-TG) fractions. The addition of CHO to the fat meal increased plasma glucose 
      and insulin concentrations identically in men and women. In contrast, adding CHO 
      to the fat meal reduced the plasma TG concentration in the 5 h after the meal in 
      women (average 5 h [TG]: 1.27 +/- 0.11 and 1.01 +/- 0.09 mmol.L(-1); p <0.05), 
      but not in men (1.25 +/- 0.23 and 1.24 +/- 0.20 mmol.L(-1)). Despite differences 
      in the lipemic response to the meals between men and women, we found that adding 
      carbohydrate to a fat meal decreased the bioavailability of meal-derived 
      [13C]-palmitate in the systemic fatty acid pool, and decreased the incorporation 
      of [13C]-palmitate into VLDL-TG in both men and women. In summary, adding CHO to 
      a fat meal markedly blunted the plasma TG response in women, but not in men, 
      which may augment the atherogenic potential after each meal in men.
FAU - Knuth, Nicolas D
AU  - Knuth ND
AD  - Substrate Metabolism Laboratory, Division of Kinesiology, University of Michigan, 
      Ann Arbor, MI 48109-2214, USA.
FAU - Remias, David B
AU  - Remias DB
FAU - Horowitz, Jeffrey F
AU  - Horowitz JF
LA  - eng
GR  - M01 RR 00042/RR/NCRR NIH HHS/United States
GR  - P60 DK 20572/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - Canada
TA  - Appl Physiol Nutr Metab
JT  - Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition 
      et metabolisme
JID - 101264333
RN  - 0 (Blood Glucose)
RN  - 0 (Chylomicrons)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 0 (Fatty Acids)
RN  - 0 (Insulin)
RN  - 0 (Lipids)
RN  - 0 (Lipoproteins, VLDL)
RN  - 0 (Palmitates)
SB  - IM
MH  - Adult
MH  - Blood Glucose/metabolism
MH  - Body Composition/physiology
MH  - Breath Tests
MH  - Chylomicrons/blood
MH  - Dietary Carbohydrates/*pharmacology
MH  - Dietary Fats/*pharmacology
MH  - Fatty Acids/*blood
MH  - Female
MH  - Humans
MH  - Insulin/blood
MH  - Lipids/*blood
MH  - Lipoproteins, VLDL/blood
MH  - Male
MH  - Oxidation-Reduction
MH  - Palmitates/blood
MH  - Postprandial Period/*physiology
MH  - Sex Characteristics
EDAT- 2008/03/19 09:00
MHDA- 2008/08/30 09:00
CRDT- 2008/03/19 09:00
PHST- 2008/03/19 09:00 [pubmed]
PHST- 2008/08/30 09:00 [medline]
PHST- 2008/03/19 09:00 [entrez]
AID - h07-190 [pii]
AID - 10.1139/H07-190 [doi]
PST - ppublish
SO  - Appl Physiol Nutr Metab. 2008 Apr;33(2):315-25. doi: 10.1139/H07-190.