PMID- 18347976
OWN - NLM
STAT- MEDLINE
DCOM- 20081126
LR  - 20221207
IS  - 0282-0080 (Print)
IS  - 0282-0080 (Linking)
VI  - 25
IP  - 6
DP  - 2008 Aug
TI  - The markers of inflammation and endothelial dysfunction in correlation with 
      glycated haemoglobin are present in type 2 diabetes mellitus patients but not in 
      their relatives.
PG  - 573-9
LID - 10.1007/s10719-008-9118-8 [doi]
AB  - The aim of this study is to test several biomarkers of inflammation, of 
      endothelial dysfunction, glycated haemoglobin, and their reflection in arterial 
      dilatation, in patients with type 2 diabetes mellitus and in their relatives, in 
      order to demonstrate if relatives present markers as a form of precocious 
      indicators of diabetes mellitus. Individuals between 30 and 55 years of age and 
      without clinical arterial disease were divided in three groups: type 2 diabetes 
      mellitus patients without complications (12 men and 18 women); first degree 
      relatives of type 2 diabetes mellitus (14 men and 20 women); and control 
      individuals (9 men and 16 women). Body composition was measured with a 
      bioelectrical impedance analyzer and endothelial function with an eco-Doppler 
      device. We determined glucose, insulin, C-peptide, glycated haemoglobin, 
      fibrinogen, E-selectin, P-selectin, soluble intercellular cell adhesion 
      molecule-1 (ICAM-1), soluble vascular cell adhesion molecule-1 (VCAM-1), 
      interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), C-reactive 
      protein (CRP) in plasma. We also studied endothelium independent dilatation and 
      endothelium dependent dilatation. THE RESULTS: ICAM-1 and VCAM-1 were 
      significantly higher in the diabetic group (237.5+/-43.4 and 692.5+/-168.6 ng/l) 
      than in controls (197.4+/-51.2 and 573.5+/-121.1 ng/l, p=0.011 and 0.013, 
      respectively), but were not higher in the family group (224.5+/-45.2 and 
      599.8+/-150.4 ng/l). CRP was higher in the diabetic group (3.35+/-3.27 mg/l) than 
      in the other groups (1.28+/-1.29 and 1.61+/-1.54 mg/l, p=0.002) and correlated 
      with glycated haemoglobin. The non-endothelium mediated dilatation was lesser in 
      the diabetic group than in the family group (17.3+/-6.1 vs. 24+/-8, p=0.029) and 
      controls. In conclusion patients with uncomplicated type 2 diabetes, but not 
      their relatives, have biochemical markers of sub-clinical inflammation in 
      relationship with glycated haemoglobin and dysfunction of the endothelial cells 
      markers. In these patients endothelium independent dilatation is more affected 
      than endothelium dependent dilatation.
FAU - Gomez, Jose Manuel
AU  - Gomez JM
AD  - Department of Endocrinology and Nutrition, University Hospital of Bellvitge, 
      Barcelona, Spain. jmgs@csub.scs.es
FAU - Vila, Ramon
AU  - Vila R
FAU - Catalina, Pablo
AU  - Catalina P
FAU - Soler, Juan
AU  - Soler J
FAU - Badimon, Lina
AU  - Badimon L
FAU - Sahun, Manel
AU  - Sahun M
LA  - eng
PT  - Journal Article
DEP - 20080318
PL  - United States
TA  - Glycoconj J
JT  - Glycoconjugate journal
JID - 8603310
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (E-Selectin)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Insulin)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 9001-32-5 (Fibrinogen)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Biomarkers/*blood
MH  - Blood Glucose/metabolism
MH  - C-Reactive Protein/metabolism
MH  - Diabetes Mellitus, Type 2/*blood/pathology/physiopathology
MH  - E-Selectin/blood
MH  - Endothelium, Vascular/*physiopathology
MH  - Female
MH  - Fibrinogen/metabolism
MH  - Glycated Hemoglobin/*metabolism
MH  - Hemodynamics
MH  - Humans
MH  - Inflammation/*blood/pathology/physiopathology
MH  - Insulin/blood
MH  - Intercellular Adhesion Molecule-1/blood
MH  - Male
MH  - Middle Aged
MH  - Vascular Cell Adhesion Molecule-1/blood
EDAT- 2008/03/19 09:00
MHDA- 2008/12/17 09:00
CRDT- 2008/03/19 09:00
PHST- 2007/11/05 00:00 [received]
PHST- 2008/02/14 00:00 [accepted]
PHST- 2008/02/13 00:00 [revised]
PHST- 2008/03/19 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/03/19 09:00 [entrez]
AID - 10.1007/s10719-008-9118-8 [doi]
PST - ppublish
SO  - Glycoconj J. 2008 Aug;25(6):573-9. doi: 10.1007/s10719-008-9118-8. Epub 2008 Mar 
      18.