PMID- 18348044
OWN - NLM
STAT- MEDLINE
DCOM- 20081110
LR  - 20191210
IS  - 1944-0057 (Electronic)
IS  - 1944-0057 (Linking)
VI  - 25
IP  - 4
DP  - 2008 Apr
TI  - Novel approach to fast determination of multiple pesticide residues using 
      ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS).
PG  - 444-57
LID - 10.1080/02652030701570156 [doi]
AB  - A rapid, high-throughput method employing ultra-performance liquid chromatography 
      with tandem quadrupole mass spectrometry (UPLC-MS/MS) was developed and optimized 
      for simultaneous quantification and confirmation of 64 pesticide residues and 
      their toxic metabolites in fruit extracts prepared by a buffered QuEChERS 
      procedure. The total time required for UPLC-MS/MS analysis was 8 min plus 2 min 
      for re-equilibration to the initial UPLC conditions. Performance characteristics 
      were determined for apple extracts spiked at 10 microg kg(-1). The repeatability 
      of measurements expressed as relative standard deviations was in the range 
      1.5-13% at this level for most analytes. Thanks to very low limits of 
      quantification (<10 microg kg(-1)for the majority of pesticides), an optimized 
      method allows for the reliable control of not only common maximum residue limits 
      (MRLs) set by European Union regulation for various pesticides/fruit 
      combinations, but also of a uniform MRL of 10 microg kg(-1)endorsed for baby 
      food.
FAU - Kovalczuk, T
AU  - Kovalczuk T
AD  - Department of Food Chemistry and Analysis, Institute of Chemical Technology, 
      Technicka 3, CZ-166 28 Prague 6, Czech Republic.
FAU - Lacina, O
AU  - Lacina O
FAU - Jech, M
AU  - Jech M
FAU - Poustka, J
AU  - Poustka J
FAU - Hajslova, J
AU  - Hajslova J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
PL  - England
TA  - Food Addit Contam Part A Chem Anal Control Expo Risk Assess
JT  - Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & 
      risk assessment
JID - 101485040
RN  - 0 (Pesticide Residues)
SB  - IM
MH  - Calibration
MH  - Chromatography, High Pressure Liquid/*methods
MH  - European Union
MH  - Humans
MH  - Infant
MH  - Infant Food/standards
MH  - Malus/*chemistry
MH  - Maximum Allowable Concentration
MH  - Pesticide Residues/*analysis
MH  - Quality Control
MH  - Reference Standards
MH  - Reproducibility of Results
MH  - Tandem Mass Spectrometry/*methods
MH  - Time Factors
EDAT- 2008/03/19 09:00
MHDA- 2008/11/11 09:00
CRDT- 2008/03/19 09:00
PHST- 2008/03/19 09:00 [pubmed]
PHST- 2008/11/11 09:00 [medline]
PHST- 2008/03/19 09:00 [entrez]
AID - 790131527 [pii]
AID - 10.1080/02652030701570156 [doi]
PST - ppublish
SO  - Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2008 
      Apr;25(4):444-57. doi: 10.1080/02652030701570156.