PMID- 18348188
OWN - NLM
STAT- MEDLINE
DCOM- 20080708
LR  - 20131121
IS  - 0022-4790 (Print)
IS  - 0022-4790 (Linking)
VI  - 97
IP  - 6
DP  - 2008 May 1
TI  - A new limb salvage surgery in cases of high-grade soft tissue sarcoma using 
      photodynamic surgery, followed by photo- and radiodynamic therapy with acridine 
      orange.
PG  - 523-8
LID - 10.1002/jso.21025 [doi]
AB  - BACKGROUND: To maintain excellent limb function after tumor resection in patients 
      with high-grade malignant sarcomas, we developed and established a new surgical 
      adjuvant therapy using acridine orange (AO) after intra-lesional or marginal 
      resection while sparing normal tissues of major nerves, vessels or bones adjacent 
      to the tumor. METHOD: Our AO therapy procedure was combined with photodynamic 
      surgery (PDS), photodynamic therapy (PDT) and radiodynamic therapy (RDT). In this 
      study, 26 patients with primary high-grade soft tissue sarcomas were treated with 
      AO therapy. RESULT: Results showed a low local recurrence rate (7.7%) and good 
      local recurrence-free rate (88%) after AO therapy. Limb function of all patients 
      was maintained at 100% of ISOLS criteria. CONCLUSION: Based on these results, we 
      concluded that AO therapy is useful for local control after margin-positive tumor 
      resection and for preserving excellent limb function in patients with high-grade 
      soft tissue sarcomas.
CI  - (c) 2008 Wiley-Liss, Inc.
FAU - Nakamura, Tomoki
AU  - Nakamura T
AD  - Department of Orthopaedic Surgery, Mie University Postgraduate School of 
      Medicine, Tsu City, Japan. tomoki66@clin.medic.mie-u.ac.jp
FAU - Kusuzaki, Katsuyuki
AU  - Kusuzaki K
FAU - Matsubara, Takao
AU  - Matsubara T
FAU - Matsumine, Akihiko
AU  - Matsumine A
FAU - Murata, Hiroaki
AU  - Murata H
FAU - Uchida, Atsumasa
AU  - Uchida A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Surg Oncol
JT  - Journal of surgical oncology
JID - 0222643
RN  - 0 (Fluorescent Dyes)
RN  - F30N4O6XVV (Acridine Orange)
SB  - IM
MH  - Acridine Orange/*therapeutic use
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Bone Neoplasms/drug therapy/radiotherapy/*therapy
MH  - Child
MH  - Child, Preschool
MH  - Combined Modality Therapy
MH  - Female
MH  - Fluorescent Dyes/*therapeutic use
MH  - Humans
MH  - Infant
MH  - *Limb Salvage
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/prevention & control
MH  - *Photochemotherapy
MH  - Radiotherapy, Adjuvant
MH  - Sarcoma/drug therapy/radiotherapy/*therapy
MH  - Soft Tissue Neoplasms/drug therapy/radiotherapy/*therapy
MH  - Treatment Outcome
MH  - X-Ray Therapy
EDAT- 2008/03/19 09:00
MHDA- 2008/07/09 09:00
CRDT- 2008/03/19 09:00
PHST- 2008/03/19 09:00 [pubmed]
PHST- 2008/07/09 09:00 [medline]
PHST- 2008/03/19 09:00 [entrez]
AID - 10.1002/jso.21025 [doi]
PST - ppublish
SO  - J Surg Oncol. 2008 May 1;97(6):523-8. doi: 10.1002/jso.21025.