PMID- 18348311
OWN - NLM
STAT- MEDLINE
DCOM- 20080530
LR  - 20211020
IS  - 0887-8013 (Print)
IS  - 1098-2825 (Electronic)
IS  - 0887-8013 (Linking)
VI  - 22
IP  - 2
DP  - 2008
TI  - Preliminary clinical measurement of the expression of TNF-related apoptosis 
      inducing ligand in patients with ankylosing spondylitis.
PG  - 138-45
LID - 10.1002/jcla.20231 [doi]
AB  - It has recently been reported that tumor necrosis factor (TNF)-related apoptosis 
      inducing ligand (TRAIL) plays various roles in such autoimmune diseases as 
      diabetes, multiple sclerosis (MS), and systemic lupus erythematosus (SLE). 
      However, it has still remained unclear whether there is a close relationship 
      between TRAIL and ankylosing spondylitis (AS). In this study, we investigated the 
      association between the expression of TRAIL and AS. The specific messenger 
      ribonucleic acid (mRNA) levels of TRAIL in peripheral blood mononuclear cells 
      (PBMCs), serum sTRAIL, and TNF-alpha concentrations from 60 AS patients, 20 
      rheumatoid arthritis (RA) patients, and 30 healthy controls were determined by 
      real-time fluorescent quantitative polymerase chain reaction (PCR) and 
      enzyme-linked immunosorbent assay (ELISA). The results indicated that the 
      expression levels of TRAIL mRNA, and serum sTRAIL were significantly elevated in 
      AS patients, compared with RA patients and healthy controls, and there was a 
      close association between TRAIL mRNA and sTRAIL levels. However, there was no 
      significant difference between human leukocyte antigen (HLA)-B27-positive and 
      -negative AS patients. In HLA-B27-positive patients, TRAIL mRNA and sTRAIL 
      closely correlated with serum TNF-alpha and C-reactive protein (CRP), but did not 
      correlate in HLA-B27-negative patients. In conclusion, upregulated expression of 
      TRAIL might be somewhat specific for evaluation of AS.
CI  - (Copyright ) 2008 Wiley-Liss, Inc.
FAU - Zai-Xing, Yang
AU  - Zai-Xing Y
AD  - Department of Laboratory Diagnostics, Changzheng Hospital, Second Military 
      Medical University, Shanghai, China.
FAU - Yan, Liang
AU  - Yan L
FAU - Hao, Wang
AU  - Hao W
FAU - Ye, Zhu
AU  - Ye Z
FAU - Chang, Li
AU  - Chang L
FAU - Ren-Qian, Zhong
AU  - Ren-Qian Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Lab Anal
JT  - Journal of clinical laboratory analysis
JID - 8801384
RN  - 0 (RNA, Messenger)
RN  - 0 (TNF-Related Apoptosis-Inducing Ligand)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Arthritis, Rheumatoid/genetics
MH  - Base Sequence
MH  - Blood Sedimentation
MH  - C-Reactive Protein/metabolism
MH  - Case-Control Studies
MH  - Electrophoresis, Agar Gel
MH  - Female
MH  - Gene Expression Regulation
MH  - Humans
MH  - Leukocytes, Mononuclear/metabolism
MH  - Male
MH  - Molecular Sequence Data
MH  - Plasmids/genetics
MH  - RNA, Messenger/genetics/metabolism
MH  - Reference Standards
MH  - Sequence Analysis, DNA
MH  - Solubility
MH  - Spondylitis, Ankylosing/*genetics
MH  - TNF-Related Apoptosis-Inducing Ligand/blood/*genetics/metabolism
MH  - Tumor Necrosis Factor-alpha/blood
PMC - PMC6649006
EDAT- 2008/03/19 09:00
MHDA- 2008/05/31 09:00
PMCR- 2008/03/17
CRDT- 2008/03/19 09:00
PHST- 2008/03/19 09:00 [pubmed]
PHST- 2008/05/31 09:00 [medline]
PHST- 2008/03/19 09:00 [entrez]
PHST- 2008/03/17 00:00 [pmc-release]
AID - JCLA20231 [pii]
AID - 10.1002/jcla.20231 [doi]
PST - ppublish
SO  - J Clin Lab Anal. 2008;22(2):138-45. doi: 10.1002/jcla.20231.