PMID- 18348771
OWN - NLM
STAT- MEDLINE
DCOM- 20080917
LR  - 20080319
IS  - 0023-6772 (Print)
IS  - 0023-6772 (Linking)
VI  - 42
IP  - 1
DP  - 2008 Jan
TI  - Prevalence of herpes B virus genome in the trigeminal ganglia of seropositive 
      cynomolgus macaques.
PG  - 99-103
LID - 10.1258/la.2007.006031 [doi]
AB  - Herpes B virus infection is almost asymptomatic in macaques (Macaca spp.), which 
      are the natural hosts of this pathogen, but is the cause of high mortality in 
      humans. Reactivation of the latent virus in the trigeminal ganglia (TG) results 
      in the shedding of infectious particles into the oral mucosal membrane. Saliva 
      contaminated with the reactivated virus from the ganglia of the natural host is 
      considered to be important for viral transmission to humans and other monkeys. In 
      the present study, we investigated the prevalence of the herpes B virus genome in 
      the left and right TG of seropositive asymptomatic cynomolgus macaques. The 
      latent virus genome was detected using a polymerase chain reaction and microplate 
      hybridization assay. We found that the virus DNA was present in one or both TG of 
      12 of the 30 macaques (40%) tested, with the virus being detected from both TG in 
      five of the 12 macaques and from a single TG in the remaining seven.
FAU - Oya, C
AU  - Oya C
AD  - Department of Veterinary Public Health, Nippon Veterinary and Life Sciences 
      University, Musashino, Tokyo 180-8602, Japan. chi1976kyu@yahoo.co.jp
FAU - Ochiai, Y
AU  - Ochiai Y
FAU - Taniuchi, Y
AU  - Taniuchi Y
FAU - Takano, T
AU  - Takano T
FAU - Fujima, A
AU  - Fujima A
FAU - Ueda, F
AU  - Ueda F
FAU - Hondo, R
AU  - Hondo R
FAU - Yoshikawa, Y
AU  - Yoshikawa Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Lab Anim
JT  - Laboratory animals
JID - 0112725
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Animals
MH  - DNA, Viral/*isolation & purification
MH  - Genome, Viral
MH  - Herpesvirus 1, Cercopithecine/*isolation & purification
MH  - Macaca fascicularis/*virology
MH  - Monkey Diseases/blood
MH  - Prevalence
MH  - Trigeminal Ganglion/*virology
EDAT- 2008/03/20 09:00
MHDA- 2008/09/18 09:00
CRDT- 2008/03/20 09:00
PHST- 2008/03/20 09:00 [pubmed]
PHST- 2008/09/18 09:00 [medline]
PHST- 2008/03/20 09:00 [entrez]
AID - 10.1258/la.2007.006031 [doi]
PST - ppublish
SO  - Lab Anim. 2008 Jan;42(1):99-103. doi: 10.1258/la.2007.006031.