PMID- 18349525
OWN - NLM
STAT- MEDLINE
DCOM- 20090109
LR  - 20080908
IS  - 1422-6421 (Electronic)
IS  - 1422-6405 (Linking)
VI  - 188
IP  - 3
DP  - 2008
TI  - Expression patterns of neurotrophins and neurotrophin receptors in articular 
      chondrocytes and inflammatory infiltrates in knee joint arthritis.
PG  - 299-309
LID - 10.1159/000121432 [doi]
AB  - BACKGROUND: It is likely that neurotrophins (NTs) are of great importance for the 
      articular cartilage and the inflammation process in arthritis. METHODS: The 
      immunohistochemical expression of the NTs nerve growth factor (NGF) and 
      brain-derived neurotrophic factor (BDNF) and the associated receptors p75, TrkA 
      and TrkB was examined in the knee joint of arthritic and healthy mice. RESULTS: 
      Immunoreactions for NGF and BDNF were detected in cells and nerve fiber 
      varicosities in the inflammatory infiltrates of the synovial tissue of arthritic 
      joints but not in synovial tissue of controls. p75-immunoreactive nerve 
      fiber-like strands were detected in inflammatory infiltrates. Immunostaining for 
      NGF, BDNF, p75, TrkA and TrkB was noted in articular chondrocytes. There was a 
      statistically significant decrease in reactions for NGF (p < 0.001), TrkA (p = 
      0.001) and p75 (p < 0.001) in articular chondrocytes in joints exhibiting severe 
      arthritis. CONCLUSION: The findings show that an NT system develops in 
      inflammatory infiltrates of the synovial tissue. Furthermore, most interestingly, 
      autocrine/paracrine effects appear to exist concerning NTs for the articular 
      chondrocytes. The downregulated expression of NGF and NT receptors in articular 
      chondrocytes in arthritis is a new aspect concerning the involvement of NTs in 
      cartilage.
CI  - Copyright 2008 S. Karger AG, Basel.
FAU - Grimsholm, Ola
AU  - Grimsholm O
AD  - Department of Integrative Medical Biology, Section for Anatomy, Umea University, 
      Umea, Sweden. ola.grimsholm@anatomy.umu.se
FAU - Guo, Yongzhi
AU  - Guo Y
FAU - Ny, Tor
AU  - Ny T
FAU - Forsgren, Sture
AU  - Forsgren S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080319
PL  - Switzerland
TA  - Cells Tissues Organs
JT  - Cells, tissues, organs
JID - 100883360
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Receptors, Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Arthritis, Experimental/metabolism
MH  - Cartilage, Articular/cytology
MH  - Chondrocytes/*metabolism
MH  - Immunohistochemistry
MH  - Inflammation/metabolism
MH  - Knee Joint/*metabolism/pathology
MH  - Male
MH  - Mice
MH  - Nerve Growth Factors/*biosynthesis
MH  - Receptors, Nerve Growth Factor/*biosynthesis
EDAT- 2008/03/20 09:00
MHDA- 2009/01/10 09:00
CRDT- 2008/03/20 09:00
PHST- 2007/11/27 00:00 [accepted]
PHST- 2008/03/20 09:00 [pubmed]
PHST- 2009/01/10 09:00 [medline]
PHST- 2008/03/20 09:00 [entrez]
AID - 000121432 [pii]
AID - 10.1159/000121432 [doi]
PST - ppublish
SO  - Cells Tissues Organs. 2008;188(3):299-309. doi: 10.1159/000121432. Epub 2008 Mar 
      19.