PMID- 18350145
OWN - NLM
STAT- MEDLINE
DCOM- 20080808
LR  - 20211020
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 3
IP  - 3
DP  - 2008 Mar 19
TI  - Association of the estrogen receptor 1 (ESR1) gene with body height in adult 
      males from two Swedish population cohorts.
PG  - e1807
LID - 10.1371/journal.pone.0001807 [doi]
LID - e1807
AB  - Human body height is a complex genetic trait with high heritability. We performed 
      an association study of 17 candidate genes for height in the Uppsala Longitudinal 
      Study of Adult Men (ULSAM) that consists of 1153 elderly men of age 70 born in 
      the central region of Sweden. First we genotyped a panel of 137 single nucleotide 
      polymorphism (SNPs) evenly distributed across the candidate genes in the ULSAM 
      cohort. We identified 4 SNPs in the estrogen receptor gene (ESR1) on chromosome 
      6q25.1 with suggestive signals of association (p<0.05) with standing body height. 
      This result was followed up by genotyping the same 25 SNPs in the ESR1 gene as in 
      ULSAM in a second population cohort, the Prospective Investigation of the 
      Vasculature in Uppsala Seniors (PIVUS) cohort that consist of 507 males and 509 
      females of age 70 from the same geographical region as ULSAM. One SNP, rs2179922 
      located in intron 4 of ESR1 showed and association signal (p = 0.0056) in the 
      male samples from the PIVUS cohort. Homozygote carriers of the G-allele of the 
      SNP rs2179922 were on average 0.90 cm taller than individuals with the two other 
      genotypes at this SNP in the ULSAM cohort and 2.3 cm taller in the PIVUS cohort. 
      No association was observed for the females in the PIVUS cohort.
FAU - Dahlgren, Andreas
AU  - Dahlgren A
AD  - Molecular Medicine, Department of Medical Sciences, Uppsala University, Uppsala, 
      Sweden.
FAU - Lundmark, Per
AU  - Lundmark P
FAU - Axelsson, Tomas
AU  - Axelsson T
FAU - Lind, Lars
AU  - Lind L
FAU - Syvanen, Ann-Christine
AU  - Syvanen AC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080319
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (ESR1 protein, human)
RN  - 0 (Estrogen Receptor alpha)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Body Height/*genetics
MH  - Cohort Studies
MH  - Estrogen Receptor alpha/*genetics
MH  - *Genetics, Population
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
PMC - PMC2265544
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2008/03/20 09:00
MHDA- 2008/08/09 09:00
PMCR- 2008/03/19
CRDT- 2008/03/20 09:00
PHST- 2007/10/26 00:00 [received]
PHST- 2008/02/14 00:00 [accepted]
PHST- 2008/03/20 09:00 [pubmed]
PHST- 2008/08/09 09:00 [medline]
PHST- 2008/03/20 09:00 [entrez]
PHST- 2008/03/19 00:00 [pmc-release]
AID - 07-PONE-RA-02588R1 [pii]
AID - 10.1371/journal.pone.0001807 [doi]
PST - epublish
SO  - PLoS One. 2008 Mar 19;3(3):e1807. doi: 10.1371/journal.pone.0001807.