PMID- 18353732
OWN - NLM
STAT- MEDLINE
DCOM- 20080904
LR  - 20220330
IS  - 1525-5069 (Electronic)
IS  - 1525-5050 (Linking)
VI  - 13
IP  - 1
DP  - 2008 Jul
TI  - Strategies to detect adverse effects of antiepileptic drugs in clinical practice.
PG  - 178-83
LID - 10.1016/j.yebeh.2008.02.006 [doi]
AB  - OBJECTIVE: The aim was to study the frequency and types of adverse effects (AEs) 
      in patients treated with antiepileptic drugs (AEDs) according to the strategies 
      used by the neurologist to detect them. METHOD: This cross-sectional 
      epidemiological study was carried out in standard clinical practice. Two 
      strategies were used to detect AEs: spontaneous reporting by the patient, and a 
      checklist of possible treatment-related adverse reactions completed by the 
      patient. RESULTS: A total of 579 patients were recruited for the study. Roughly a 
      third (33.7%) reported AEs spontaneously, and 65.2% did so when administered the 
      checklist. The main reason for changing medication was lack of efficacy, but 
      significant side effects were also an important reason for modifying treatment in 
      those patients who reported higher levels of discomfort. CONCLUSIONS: The use of 
      an active approach is recommended for detection of AEs of AED treatment. AEs 
      appear to have a key effect on the decision to change treatment.
FAU - Carreno, M
AU  - Carreno M
AD  - Epilepsy Unit, Neurology Service, Hospital Clinic i Provincial, Barcelona, Spain. 
      mcarreno@clinic.ub.es
FAU - Gil-Nagel, A
AU  - Gil-Nagel A
FAU - Sanchez, J C
AU  - Sanchez JC
FAU - Elices, E
AU  - Elices E
FAU - Serratosa, J M
AU  - Serratosa JM
FAU - Salas-Puig, J
AU  - Salas-Puig J
FAU - Villanueva, V
AU  - Villanueva V
FAU - Porcel, J
AU  - Porcel J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080318
PL  - United States
TA  - Epilepsy Behav
JT  - Epilepsy & behavior : E&B
JID - 100892858
RN  - 0 (Anticonvulsants)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Adverse Drug Reaction Reporting Systems/*statistics & numerical data
MH  - Aged
MH  - Anticonvulsants/*adverse effects
MH  - Cross-Sectional Studies
MH  - Epilepsy/*drug therapy/*epidemiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
EDAT- 2008/03/21 09:00
MHDA- 2008/09/05 09:00
CRDT- 2008/03/21 09:00
PHST- 2007/12/03 00:00 [received]
PHST- 2008/02/06 00:00 [revised]
PHST- 2008/02/06 00:00 [accepted]
PHST- 2008/03/21 09:00 [pubmed]
PHST- 2008/09/05 09:00 [medline]
PHST- 2008/03/21 09:00 [entrez]
AID - S1525-5050(08)00021-8 [pii]
AID - 10.1016/j.yebeh.2008.02.006 [doi]
PST - ppublish
SO  - Epilepsy Behav. 2008 Jul;13(1):178-83. doi: 10.1016/j.yebeh.2008.02.006. Epub 
      2008 Mar 18.