PMID- 18353802
OWN - NLM
STAT- MEDLINE
DCOM- 20080819
LR  - 20111117
IS  - 1460-2407 (Electronic)
IS  - 1360-9947 (Linking)
VI  - 14
IP  - 5
DP  - 2008 May
TI  - Paternal contribution of HLA-G*0106 significantly increases risk for 
      pre-eclampsia in multigravid pregnancies.
PG  - 317-24
LID - 10.1093/molehr/gan013 [doi]
AB  - Pre-eclampsia (PE) is a leading cause of maternal and fetal mortality and 
      morbidity. Structural or functional alterations of human leukocyte antigen 
      (HLA)-G present at the maternal-fetal interface may predispose women to PE. We 
      tested the HLA-G gene for association with PE in a case-control study of 83 PE 
      and 240 normotensive Malay women. HLA-G was amplified in a single-tube 
      multiplex-PCR reaction and genotyped for 18 single nucleotide polymorphisms 
      (SNPs) by multiplex-minisequencing. Case-control comparisons were performed, and 
      associations with disease were expressed as odds ratios (ORs). Risk for PE was 
      significantly associated with fetal allele G*0106 only in multigravid pregnancies 
      (P = 0.002, OR = 5.0, 95% CI = 1.8-13.8). Among multigravid pregnancies, the 
      frequency of PE babies heterozygous or homozygous for G*0106 was also 
      significantly higher compared with normal control babies (P = 0.002, OR = 5.4, 
      95% CI = 1.9-15.4). Multivariate analyses with adjustment for factors associated 
      with PE revealed similar results (P = 0.003, OR = 10.1, 95% CI = 2.2-46.8). 
      Additionally, a significantly higher frequency of fetal-maternal G*0106 genotype 
      mismatch was observed in PE compared with normal multigravid pregnancies (P = 
      0.001, OR = 9.6, 95% CI = 2.4-38.7). Thus, paternal HLA-G G*0106 contribution 
      significantly increases risk for PE in multigravidas who do not carry this 
      allele, potentially mediated by a gradual maternal alloimmune response to 
      repeated exposure to the paternal HLA-G variant.
FAU - Tan, Chia Yee
AU  - Tan CY
AD  - Department of Pediatrics, Yong Loo Lin School of Medicine, National University of 
      Singapore, 5 Lower Kent Ridge Road, 119074 Singapore, Singapore.
FAU - Ho, Julia F V
AU  - Ho JF
FAU - Chong, Yap Seng
AU  - Chong YS
FAU - Loganath, Annamalai
AU  - Loganath A
FAU - Chan, Yiong Huak
AU  - Chan YH
FAU - Ravichandran, Jeganathan
AU  - Ravichandran J
FAU - Lee, Caroline G
AU  - Lee CG
FAU - Chong, Samuel S
AU  - Chong SS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080319
PL  - England
TA  - Mol Hum Reprod
JT  - Molecular human reproduction
JID - 9513710
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (HLA-G*01:06 antigen)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adult
MH  - Base Sequence
MH  - Case-Control Studies
MH  - DNA Mutational Analysis
MH  - *Fathers
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - *Gravidity/genetics
MH  - HLA Antigens/*genetics/immunology
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Infant, Newborn
MH  - Inheritance Patterns
MH  - Male
MH  - Maternal-Fetal Exchange/genetics
MH  - Polymorphism, Single Nucleotide
MH  - Pre-Eclampsia/*genetics
MH  - Pregnancy
MH  - Risk Factors
EDAT- 2008/03/21 09:00
MHDA- 2008/08/20 09:00
CRDT- 2008/03/21 09:00
PHST- 2008/03/21 09:00 [pubmed]
PHST- 2008/08/20 09:00 [medline]
PHST- 2008/03/21 09:00 [entrez]
AID - gan013 [pii]
AID - 10.1093/molehr/gan013 [doi]
PST - ppublish
SO  - Mol Hum Reprod. 2008 May;14(5):317-24. doi: 10.1093/molehr/gan013. Epub 2008 Mar 
      19.