PMID- 1835390
OWN - NLM
STAT- MEDLINE
DCOM- 19911230
LR  - 20081121
IS  - 0904-1850 (Print)
IS  - 0904-1850 (Linking)
VI  - 13
DP  - 1991 Apr
TI  - Regulation of IgE production in mice.
PG  - 97s-104s
AB  - Helper T-lymphocytes tightly regulate the proliferation and antibody production 
      of B-lymphocytes by a variety of molecules called lymphokines. Molecular biology 
      has provided the tools to produce large amounts of these regulatory molecules in 
      highly purified "recombinant" form. Furthermore, monoclonal antibodies have been 
      produced that selectively neutralize each of these lymphokines. This enables 
      thorough investigation of the regulation of human and murine immunoglobulin E 
      (IgE) production. This paper reviews recent data on the regulation of murine IgE 
      production by lymphokines produced by distinct helper T-cell clones. Special 
      attention is paid to the IgE enhancing activity of interleukin-4 (IL-4) and the 
      IgE inhibiting activity of interferon-gamma (IFN-gamma). Evidence is presented 
      that these lymphokines also play a crucial role in genetically determined IgE 
      "high responder" and IgE "low responder" mouse strains.
FAU - Benner, R
AU  - Benner R
AD  - Dept of Immunology, Erasmus University, Rotterdam, The Netherlands.
FAU - Savelkoul, H F
AU  - Savelkoul HF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Eur Respir J Suppl
JT  - The European respiratory journal. Supplement
JID - 8910681
RN  - 0 (Lymphokines)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - B-Lymphocytes/immunology
MH  - Clone Cells
MH  - Immunoglobulin E/*biosynthesis
MH  - Interferon-gamma/physiology
MH  - Interleukin-4/physiology
MH  - Lymphokines/*physiology
MH  - Mice
MH  - T-Lymphocytes, Helper-Inducer/*physiology
RF  - 57
EDAT- 1991/04/01 00:00
MHDA- 1991/04/01 00:01
CRDT- 1991/04/01 00:00
PHST- 1991/04/01 00:00 [pubmed]
PHST- 1991/04/01 00:01 [medline]
PHST- 1991/04/01 00:00 [entrez]
PST - ppublish
SO  - Eur Respir J Suppl. 1991 Apr;13:97s-104s.