PMID- 18354419
OWN - NLM
STAT- MEDLINE
DCOM- 20080716
LR  - 20080423
IS  - 1476-5470 (Electronic)
IS  - 1466-4879 (Linking)
VI  - 9
IP  - 3
DP  - 2008 Apr
TI  - IL2RA and IL7RA genes confer susceptibility for multiple sclerosis in two 
      independent European populations.
PG  - 259-63
LID - 10.1038/gene.2008.14 [doi]
AB  - Multiple sclerosis (MS) is the most common chronic inflammatory neurologic 
      disorder diagnosed in young adults and, due to its chronic course, is responsible 
      for a substantial economic burden. MS is considered to be a multifactorial 
      disease in which both genetic and environmental factors intervene. The 
      well-established human leukocyte antigen (HLA) association does not completely 
      explain the genetic impact on disease susceptibility. However, identification and 
      validation of non-HLA-genes conferring susceptibility to MS has proven to be 
      difficult probably because of the small individual contribution of each of these 
      genes. Recently, associations with two single nucleotide polymorphisms (SNPs) in 
      the IL2RA gene (rs12722489, rs2104286) and one SNP in the IL7RA gene (rs6897932) 
      have been reported by several groups. These three SNPs were genotyped in a French 
      and a German population of MS patients using the hME assay by the matrix-assisted 
      laser desorption/ionization time of flight technology (Sequenom, San Diego, CA, 
      USA). We show that these SNPs do contribute to the risk of MS in these two 
      unrelated European MS patient populations with odds ratios varying from 1.1 to 
      1.5. The discovery and validation of new genetic risk factors in independent 
      populations may help toward the understanding of MS pathogenesis by providing 
      valuable information on biological pathways to be investigated.
FAU - Weber, F
AU  - Weber F
AD  - Max Planck Institute of Psychiatry, Munich, Germany. fweber@mpipsykl.mpg.de
FAU - Fontaine, B
AU  - Fontaine B
FAU - Cournu-Rebeix, I
AU  - Cournu-Rebeix I
FAU - Kroner, A
AU  - Kroner A
FAU - Knop, M
AU  - Knop M
FAU - Lutz, S
AU  - Lutz S
FAU - Muller-Sarnowski, F
AU  - Muller-Sarnowski F
FAU - Uhr, M
AU  - Uhr M
FAU - Bettecken, T
AU  - Bettecken T
FAU - Kohli, M
AU  - Kohli M
FAU - Ripke, S
AU  - Ripke S
FAU - Ising, M
AU  - Ising M
FAU - Rieckmann, P
AU  - Rieckmann P
FAU - Brassat, D
AU  - Brassat D
FAU - Semana, G
AU  - Semana G
FAU - Babron, M-C
AU  - Babron MC
FAU - Mrejen, S
AU  - Mrejen S
FAU - Gout, C
AU  - Gout C
FAU - Lyon-Caen, O
AU  - Lyon-Caen O
FAU - Yaouanq, J
AU  - Yaouanq J
FAU - Edan, G
AU  - Edan G
FAU - Clanet, M
AU  - Clanet M
FAU - Holsboer, F
AU  - Holsboer F
FAU - Clerget-Darpoux, F
AU  - Clerget-Darpoux F
FAU - Muller-Myhsok, B
AU  - Muller-Myhsok B
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080320
PL  - England
TA  - Genes Immun
JT  - Genes and immunity
JID - 100953417
RN  - 0 (IL2RA protein, human)
RN  - 0 (Interleukin-2 Receptor alpha Subunit)
RN  - 0 (Receptors, Interleukin-7)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - France
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Germany
MH  - Humans
MH  - Interleukin-2 Receptor alpha Subunit/*genetics
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/*genetics
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Receptors, Interleukin-7/*genetics
MH  - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
EDAT- 2008/03/21 09:00
MHDA- 2008/07/17 09:00
CRDT- 2008/03/21 09:00
PHST- 2008/03/21 09:00 [pubmed]
PHST- 2008/07/17 09:00 [medline]
PHST- 2008/03/21 09:00 [entrez]
AID - gene200814 [pii]
AID - 10.1038/gene.2008.14 [doi]
PST - ppublish
SO  - Genes Immun. 2008 Apr;9(3):259-63. doi: 10.1038/gene.2008.14. Epub 2008 Mar 20.