PMID- 18354728
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1687-4757 (Print)
IS  - 1687-4765 (Electronic)
VI  - 2008
DP  - 2008
TI  - The role of peroxisome proliferator-activated receptors in the development and 
      physiology of gametes and preimplantation embryos.
PG  - 732303
LID - 10.1155/2008/732303 [doi]
LID - 732303
AB  - In several species, a family of nuclear receptors, the peroxisome 
      proliferator-activated receptors (PPARs) composed of three isotypes, is expressed 
      in somatic cells and germ cells of the ovary as well as the testis. Invalidation 
      of these receptors in mice or stimulation of these receptors in vivo or in vitro 
      showed that each receptor has physiological roles in the gamete maturation or the 
      embryo development. In addition, synthetic PPAR gamma ligands are recently used 
      to induce ovulation in women with polycystic ovary disease. These results reveal 
      the positive actions of PPAR in reproduction. On the other hand, xenobiotics 
      molecules (in herbicides, plasticizers, or components of personal care products), 
      capable of activating PPAR, may disrupt normal PPAR functions in the ovary or the 
      testis and have consequences on the quality of the gametes and the embryos. 
      Despite the recent data obtained on the biological actions of PPARs in 
      reproduction, relatively little is known about PPARs in gametes and embryos. This 
      review summarizes the current knowledge on the expression and the function of 
      PPARs as well as their partners, retinoid X receptors (RXRs), in germ cells and 
      preimplantation embryos. The effects of natural and synthetic PPAR ligands will 
      also be discussed from the perspectives of reproductive toxicology and assisted 
      reproductive technology.
FAU - Huang, Jaou-Chen
AU  - Huang JC
AD  - Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, 
      Gynecology and Reproductive Sciences, University of Texas Medical School at 
      Houston, 6431 Fannin Street, Houston, TX 77030, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - PPAR Res
JT  - PPAR research
JID - 101269101
PMC - PMC2266973
EDAT- 2008/03/21 09:00
MHDA- 2008/03/21 09:01
PMCR- 2008/02/28
CRDT- 2008/03/21 09:00
PHST- 2007/08/22 00:00 [received]
PHST- 2007/12/04 00:00 [accepted]
PHST- 2008/03/21 09:00 [pubmed]
PHST- 2008/03/21 09:01 [medline]
PHST- 2008/03/21 09:00 [entrez]
PHST- 2008/02/28 00:00 [pmc-release]
AID - 10.1155/2008/732303 [doi]
PST - ppublish
SO  - PPAR Res. 2008;2008:732303. doi: 10.1155/2008/732303.