PMID- 18355029
OWN - NLM
STAT- MEDLINE
DCOM- 20080620
LR  - 20171116
IS  - 1526-4602 (Electronic)
IS  - 1525-7797 (Linking)
VI  - 9
IP  - 4
DP  - 2008 Apr
TI  - Porous devices derived from co-continuous polymer blends as a route for 
      controlled drug release.
PG  - 1131-8
LID - 10.1021/bm7010467 [doi]
AB  - In this study we examine the release profile of bovine serum albumin (BSA) from a 
      porous polymer matrix derived from a co-continuous polymer blend. The porosity is 
      generated through the selective extraction of one of the continuous phases. This 
      is the first study to examine the approach of using morphologically tailored 
      co-continuous polymer blends as a template for generating porous polymer 
      materials for use in controlled release. A method for the preparation of 
      polymeric capsules is introduced, and the effect of matrix pore size and surface 
      area on the BSA release profile is investigated. Furthermore, the effect of 
      surface charge on release is examined by surface modification of the porous 
      substrate using layer-by-layer deposition techniques. Synthetic, nonerodible 
      polymer, high-density polyethylene (HDPE), was used as a model substrate prepared 
      by melt blending with two different styrene-ethylene-butylene copolymers. Blends 
      with HDPE allow for the preparation of porous substrates with small pore sizes 
      (300 and 600 nm). A blend of polylactide (PLA) and polystyrene was also used to 
      prepare porous PLA with a larger pore size (1.5 microm). The extents of 
      interconnectivity, surface area, and pore dimension of the prepared porous 
      substrates were examined via gravimetric solvent extraction, BET nitrogen 
      adsorption, mercury porosimetry, and image analysis of scanning electron 
      microscopy micrographs. With a loading protocol into the porous HDPE and PLA 
      involving the alternate application of pressure and vacuum, it is shown that 
      virtually the entire porous network was accessible to BSA loading, and loading 
      efficiencies of between 80% and 96% were obtained depending on the pore size of 
      the carrier and the applied pressure. The release profile of BSA from the 
      microporous structure was monitored by UV spectrophotometry. The influence of 
      pore size, surface area, surface charge, and number of deposited layers is 
      demonstrated. It is shown that an effective closed-cell structure in porous PLA 
      can be prepared, effectively eliminating all short-term BSA release.
FAU - Salehi, Pouneh
AU  - Salehi P
AD  - CREPEC, Department of Chemical Engineering, Ecole Polytechnique de Montreal,PO 
      Box 6079 Station Centre-ville, Montreal, (QC) Canada H3C 3A7.
FAU - Sarazin, Pierre
AU  - Sarazin P
FAU - Favis, Basil D
AU  - Favis BD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080321
PL  - United States
TA  - Biomacromolecules
JT  - Biomacromolecules
JID - 100892849
RN  - 0 (Polyesters)
RN  - 0 (Polymers)
RN  - 0 (Polystyrenes)
RN  - 27432CM55Q (Serum Albumin, Bovine)
RN  - 459TN2L5F5 (poly(lactide))
RN  - 9002-88-4 (Polyethylene)
RN  - 9003-53-6 (styrofoam)
SB  - IM
MH  - Animals
MH  - Cattle
MH  - *Drug Delivery Systems
MH  - Microscopy, Electron, Scanning
MH  - Polyesters/*chemistry
MH  - Polyethylene/administration & dosage
MH  - Polymers/chemical synthesis/*chemistry
MH  - Polystyrenes/*chemistry
MH  - Porosity
MH  - Serum Albumin, Bovine/*administration & dosage
MH  - Spectrophotometry, Ultraviolet
MH  - Surface Properties
EDAT- 2008/03/22 09:00
MHDA- 2008/06/21 09:00
CRDT- 2008/03/22 09:00
PHST- 2008/03/22 09:00 [pubmed]
PHST- 2008/06/21 09:00 [medline]
PHST- 2008/03/22 09:00 [entrez]
AID - 10.1021/bm7010467 [doi]
PST - ppublish
SO  - Biomacromolecules. 2008 Apr;9(4):1131-8. doi: 10.1021/bm7010467. Epub 2008 Mar 
      21.